... at increased risk for pulmonary complications
(severe emphysema, acute respiratory distress syndrome)
were not included in the analysis – a fact that may explain
this surprising finding. In a ... catheters) [1], malposition was significantly
Commentary
What is the best site for central venous catheter insertion in
critically ill patients?
Jean-François Timsit
R...
... However, this is
the first study in this area.
Our findings raise issues for the planning of studies and ethi-
cal issues related to the obligation of the physician-researcher
to study participants ... Technicians trained in the measurement
and scoring of structural change read the MRI scans: they are
not usually trained in musculoskeletal radiology or MRI beyond
the m...
... laboratory investigations [8]. Therefore, many
lung transplant programmes use iNO routinely during early
reperfusion of the lung. Bearing in mind that the concept of
ischaemia/reperfusion injury in clinical ... and do these findings apply to
other forms of lung injury?
Ischaemia/reperfusion injury leading to initial graft failure is a
major cause of early mortality after lung transp...
... necrosis and apop-
tosis, the sepsis is associated with many other forms of cellular
stress [14], allowing for active secretion as a potential third
mechanism in this scenario.
Interestingly, in ... about 3 hours, making the test a potentially realistic and
useful one in the clinical setting (when predicting outcome
early in the course of a disease process). Finally, we us...
... functional ability may sometimes be the only
way to determine baseline HRQOL.
Response shift in critically ill patients
Patients become accustomed to their illness. An important
mechanism in this adaptive ... raised the possibility of
scoring patients at risk before discharging them home,
assessing their recovery environment and ensuring that
patients are assessed at the critica...
... prospectively collected on a daily basis by
senior physicians of the participating ICUs who are clo-
sely involved in establishing the database. For all patients,
information is recorded at baseline (including ... Thus, censoring is clearly informative (that is,
the survival time of an individual does depend on cen-
soring). In other words, informative censoring defines a
com...
... fumigatus
can invade the pulmonary parenchyma, resulting in invasive
pulmonary aspergillosis, a disease with a high lethality. More
recently, a locally invasive form called necrotizing pulmonary
aspergillosis ... defined by the European
Organisation for the Research and Treatment of Cancer/
Mycoses Study Group (EORTC/MSG), is difficult to establish in
critically ill patients...
... after packaging [4]. It may, there-
fore, be surprising not to find equal amounts of the two
subunits in virions. The reason for this is presently
unclear. It may be that different blotting efficiencies ... only the relative Gag to Pol ratios. How can this find-
ing be explained in the light of recent results in which two
distinct RNA structures were identified to be essenti...
... hypothesized that P. aeruginosa lung infection should be cleared by inhalation of fucose and ga-
lactose, which compete for the sugar binding site of the two lectins and thus inhibit the binding ... fluid.
As this elevator is driven by the beating of the cilia,
their inactivation would also facilitate the infection,
which is indeed the case as these two lectins also i...
... benefits critically ill
patients.
Key messages
• Demands for ICU beds are increa sing worldwide
and delay to ICU admission is becoming a more fre-
quent issue.
• Thereisanincreaseinmortalityforeachhourof
delay ... 44.8%).
Analysis of the delay to ICU admission by multivariate
analysis is presented in Table 3. Each w aiting hour was
associated indepe ndently with a 1.5% increase...