... present in
the intestinal lumen. This hypothesis is supported by
positioning of iNOS on the apical side of intestinal
crypts. Recently PDZ-binding a
2
⁄ b
1
-NO-sensitive
guanylate cyclase [29] ... (iNOS) protein is
responsible for sustained release of nitric oxide (NO)
and is typically synthesized in response to proinflam-
matory stimuli [1]. iNOS protein is induced in a large...
... production of several proinflamma-
tory cytokines (IL-6, IL-8 and GM-CSF) and VEGF in RA-
FLS. Since they were suppressed by an EGFR tyrosine
kinase inhibitor, the AREG-dependent induction of these
cytokines ... by
ELISAs. The proinflammatory roles were assessed by the growth-promoting and cytokine-inducing
effects of the corresponding recombinant proteins on cultured fibroblast-lik...
... Tyr. These mutations may
in uence the shape and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the ... phenylglycyl- and p-hydroxyphe-
nylglycyl-enzyme of bF24A, as indicated by, respectively, a
twofold and fourfold increased V
s
/V
h
ratiocomparedtothe
wild-type (Table 4). The V
s
/V
h
r...
... Bersselaar L,
Van den Berg WB: Reduction of interleukin-17-induced inhibi-
tion of chondrocyte proteoglycan synthesis in intact murine
articular cartilage by interleukin-4. Arthritis Rheum 2000, 43:
1300-1306.
46. ... induction of metalloproteinases by IL-17 in
synoviocytes and chondrocytes [48–50]. Interestingly, the
IL-17 family subtypes IL-17F and IL-17E also showed
cartilage des...
... to
interfere with the inflammatory response in SLE by adminis-
tering only an induction regime of four infusions of infliximab
within 10 weeks rather than by planning for long-term therapy.
Evidence ... appears to play a major pro-inflammatory
role in SLE also. The available open-label experience on
infliximab therapy in SLE suggests that, in combination with
azathioprine, infli...
... pro-inflammatory
cytokine that is produced in response to injury, exerting a
number of important roles in the immune system and
during inflammatory responses. It is of particular interest
in neuropathology ... con-
sequences in each case may enhance the inflammatory
response and the clearance of infection in acute infection,
but have potentially deleterious effects in chro...
... VEGF in the lung induces pulmonary edema with
increased lung vascular permeability, the role of VEGF in the development of acute lung injury remains to be determined.
Methods: To evaluate the role ... role of VEGF in the pathogenesis of acute lung injury, we first evaluated the effects of
exogenous VEGF and VEGF blockade using monoclonal antibody on LPS-induc...
... joint involvement and rapid
joint progression confirm observations that the frequency
of CD4
+
CD28
–
T cells may correlate with the risk of
occurrence of joint erosions in RA [18].
Competing interests
None ... protein Bcl-2 and Fas-associ-
ated with death domain-like IL-1-converting enzyme
inhibitory protein (FLIP) [16]. The absence of CTLA4
surface expression on CD28
–
T cells may...
...
University, Husargatan 3, SE-751 21 Uppsala, Sweden.
§
Key Laboratory of Zoonosis, Ministry of Education, Jilin University, Xi An Da Lu 5333,
Changchun 130062, China.
¶
Laboratory of Parasitology, ... are
known to interact with the host immune system [12]. These
include the family of P. falciparum erythrocyte membrane
protein 1 (PfEMP1) proteins, employed by the parasite to
seques...