Báo cáo y học: "Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts" docx
... al.: Amino acid substitutions in the E2
glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo
heparan sulfate-dependent infection of mouse embryonic fibroblasts.
Virology Journal ... 145-150 amino acid in the E2 glycoprotein of
Sindbis virus in the interaction with cellular heparan sulfate (HS) and in the inf...
... occurred in the hyaluronan-binding domain of the
A1D1 fraction of proteoglycan [20]. Different age-adjusted
proportions of the
D amino acids may also vary from one
another as a result of hot spots ... combination of catabolism and anabolism
could lead to the replacement of
D amino acids for L amino
acids, resulting in a reduction of the rate of
D/D+L amino...
... dysfunction may be another link. The role
of UA as a mediator of endothelial dysfunction by nitric oxide
(NO) inactivation has recently emerged [57,58]. The xanthine
oxidase system is one of the main producers ... healthy
rats in which mild hyperuricaemia, without crystal deposition,
was induced with the use of the uricase inhibitor oxonic acid.
This resulted in the...
... of mouse
Hyal2 is due to the combined action of multiple amino
acid changes acting in concert.
Interestingly, the mutation R301G increased the receptor
activity of human Hyal2 by 65%. A glycine ... Hyal2 contribute to the low activity of
mouse Hyal2. Constructs mhmm and mmhm show that
insertion of the second domain of human Hyal2 can
restore most of the a...
... protein would fold up spontaneously into
a conformation that minimizes the total free energy of the
system.
None of the protein structure predicting methods perform
satisfactorily, which is very ... similarity to the pattern obtained by SCHM.
This might indicate that no one matrix is completely inde-
pendent and distant from the natural frequency of amino
acids in the pr...
... time-
contingent intake and reduction of medication, increase of
bodily activity, reduction of interference of pain with activities,
reduction of pain behaviours, and training in assertive pain-
incompatible ... 2 = always). The total value
of pain behaviours was calculated by summing the absolute
frequencies of the individual pain behaviours observed during
the task....
... subse-
quently delivered to the neonate via the inspiratory limb
of the ventilator circuit. The resulting concentration of the
inhaled NO and NO
2
was verified in- line by using an elec-
trochemical ... therapy.
Inhalation of NO significantly decreased OI (P<0.0001)
and improved the a/A ratio (P<0.0001) within the first 2h
of INO therapy in 61.1% of the re...
... honoured only those
who contributed to the discovery of HIV rather than HPV
as well the picture may have been different. Instead they
chose to reward the two scientists most responsible for the
first ... characteristic of the early stage of acquired
immune deficiency. They detected activity of the retroviral
enzyme reverse transcriptase, a direct sign of retrovirus
r...
... treatment
either into a covered bucket or into the central venous line. The
infusion rate of fluids was set in all groups to 2 ml/kg at the
beginning of the experimental therapy. A three-way stopcock
determined ... designed the study protocol, conducted the laboratory
work and wrote the manuscript. HGW helped to design the
study protocol and was involved in laborat...
... which
appear to be increased in individuals with OSA, is due
to the conversion of xanthine dehydrogenase (type D)
into its oxidase (type O) form in hypoxia, followed by
the activation of the oxidase ... in
the homog enate, was monito red spectrophotometrically
at 480 nm. The amount of enzyme that inhibited 50% of
epinephrine auto-oxidation was defined as 1 U of S...