... resulted involved in substrate binding (Fig-
ure 4). On the contr ary in SBEIIa- D
(D462N)
the mutation
caused the loss of two of the seven amino acids involved
in the binding and catalytic activity in ... 11:156
http://www.biomedcentral.com/1471-2229/11/156
Page 9 of 14
RESEARCH ARTICLE Open Access
High resolution melting analysis for the detection
of...
... argues against a role for a3inthe
formation of native MII binding sites, but may reflect the
scarcity of these sites in the investigated brain tissues and/or
the formation of low affinity binding sites ... purpurascens
13
was again identified in a
cloning approach making use of the high conservation of
the 3¢ untranslated region and the intron preceding the
sequen...
... pathways of protein folding are reflected
in the formation of IBs and in their structure. Study-
ing protein aggregates can therefore provide a first
glimpse about the occurrence of folding-limiting
steps. ... detailed
analysis of the mode of building and of the structure
of aggregates can be useful to dissect pathways and
bottlenecks in the folding of specific...
... 9.1 points yesterday morning"
Figure 3: the transformed form of the path with dash line for the second pass processing
2.4 The statistical parameter
training
In this work, the training and ... summarize the outcomes of our
statistical model on various size of the training
data, x-coordinate denotes the size of the
training set, where "1" indicates...
... restricting the power of the gap-
resolution connective, the two stacks of the daugh-
ters are shared but not with their mother. An in-
teresting trait of PLIG is that it can generate the
language ... derivation
obtained in (25) is quite more straightforward than
the derivation in (12). The filler eats is intro-
duced on the left conjunct, while the gap of typ...
... dur-
ing lipid raft isolation. Moreover, these studies have
provided some insights into the significance of the
localization of the P2X
7
receptors in lipid rafts regard-
ing the regulation of intracellular ... (glycero-)sphingolipids. In addition the
fatty acid chains of the phospholipids composing
these rigid domains are generally more saturated than
those in the...
... topical thrombin [13]. Another consequence of
bovine thrombin exposure is the p otential development
of antibodies to human clotting proteins and thrombin,
in particular factor V, r esulting in coagul ... thrombin injection instead of arterial
embolization to avoid hepatic infarction. The rationale
for this choice may be ins ufficient. However, US-guided
percutaneous thrombin...
... existing agents.
Competing interests
The author declares that he has no competing interests.
References
1. Kaelin WG Jr: The concept of synthetic lethality in the context
of anticancer therapy. ... important role in the maintenance of
genomic stability. Loss of p53 renders tumor cells
dependent on signaling molecules such as ATM, CHEK2
and MK2 for survival in the...
... still note the best performance of the completely informed detectors (C1 and O1) and
the lowest performance of the less informed detectors (C9 and O9). We note again, for a given set of
unknown ... interest of taking the SO noncircularity of the total noise into account in the receiver’s
computation as well as the capability of the optimal receiver to perfo...
... conformations. The hydro-
xyl group of citrate points towards the internal
aldimine, as is expected for the amino group of OAS
(Fig. 2). In view of the bound citrate molecule, we
determined the ... nucleophile. TNB seems to
be most appropriate for guiding enzyme engineering
intended for the synthesis of compounds of similar
size. The activities of wild-type C...