Báo cáo khoa hoc:" Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression" potx
Báo cáo khoa hoc:" Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression" potx
... number not for citation purposes)Journal of Negative Results in BioMedicineOpen AccessResearch Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma ... combined into a single variable, the 'phe-notypic index' [17]. This index, with minimum and max-imum values of 1 and 5, represents the sum of pointsassigned to the following phenotypic ... the genotyping, participated in the selection of SNPs, analysis, and prepared the manuscript; PR and SSparticipated in the genotyping; AP coordinated the patients' accrual and updated the...
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Báo cáo khoa học: Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling pdf
... between the N-terminal and C-terminal NBD in thisregion are highlighted in ball -and- stick fashion in Fig. 5B. The first is the presence of an asparagine (Asn428) in the Walker-A motif of the N-terminal ... derivatization, and (b) occupancy of the nucleotide-binding site could alter the accessibility and reactivity of this cysteine. Therefore, the purified single-cysteine-containing fusion proteins were examined ... interaction of nucleotides with NBDs,employing the unique, reactive cysteine residue in the Walker-A sequence. The two NBDs of P-glycoprotein are functionally similar The similar time course of binding...
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Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... normal individuals) because of their inability to repair UV-induced DNA lesions. These clinical findings are associated with cellular defects, including hypersensitivity to killing and the mutagenic ... high-throughput genotyping methods will facilitate the analysis of multiple polymorphisms within genes and the analysis of multiple genes within pathways. The effects of polymorphisms are best represented ... tighter linkage disequilibrium with disease-causing mutations. In ad-dition, haplotype analysis offers the advantage of not assuming that any of the genotyped polymorphisms is functional; rather,...
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Báo cáo khoa học: Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding pdf
... twoelements in ClpA, one in the N-domain and the other in the pore of the ClpA hexamer. In the case of shortunstructured peptides or unfolded proteins such ascasein, binding to the tyrosine residues in ... threedomains: an N-domain and two ATP-binding domainsreferred to as the D1 and D2 domains. Interestingly,deletion of the N-domain from ClpA not only abol-ishes binding of the adaptor protein, ClpS, but ... by ClpP (data not shown). Thus it remainsunclear whether these arginine residues are directlyinvolved in substrate binding. Of note, although the N-domains of ClpA and p97 are not structurallyrelated,...
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Báo cáo khoa học: "Some Problems in the Mechanical Translation of German" pdf
... 3. The nominative form is identical to the ac- cusative in the feminine singular of der and welcher, in the neuter singular of der, welcher and was, and in the plural (all genders) of der and ... need not continue to discuss the solution of these first two types, since it will be contained in that of the main problem, the distinction of nominative from accusative in the feminine and ... per cent of the instances the subject, in 25 per cent of the instances the direct object, and in 45 per cent of the instances an independ- ent prepositional phrase. In the remaining 10 per...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... ([Ile8]oxytocin) are the evolutionary precursors of oxytocin [1]. The receptors that mediate the effects of thesehormones are G-protein coupled receptors (GPCRs) and include the isotocin receptor, the ... off-state. The unique ability of arginyl to fulfil this constraining function in the N-terminus of the V1aR is similar to the unique constraining role of alanyl previously reported for Ala293 in the ... stabilize the G-proteininteraction of the active receptor [28]. In summary, Arg46 of the V1aR is required for highaffinity agonist binding and signalling. It is one of the constraining residues...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx
... of analogs in the active center. Furthermore,these findings also seem to indicate that the analogs canFig. 5. Scheme of the HDC reactions with the natural substrate histidine and the histidine-analogs ... 5 min, the spectra of the HisOMe-treatedsamples had stabilized with the 390-nm peak as the major and final one. In the reaction in the presence of an excess of the natural substrate histidine, ... covalentbinding of the adduct to the catalytic center could fix somesecondary structure in the enzyme, suggesting severalinteraction points for the adduct within the catalytic center in addition...
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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... role in stabilizing the DNA–drug complex. The NH amide atoms of the drug in particular form H-bonds with thymine O2 and adenine N3 atoms in the AATT-rich sequence of the decamer. Part of the spine ... cataloging the structure to class I. As the bulky NH2group on guanine was believedto prevent binding of the drug in the minor groove, the detailed nature of several of the amidinium and guanidinium ... NH2group of GC basepairs at the floor of the minor groove was believed toprevent binding and sequence-specific hydrogen bond-ing, the detailed nature of several of the amidinium and guanidinium...
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Báo cáo khoa học: "Recent advances in the surgical care of breast cancer patients" pps
... occurred in the last two decades.Surgeons, once solely interested in the extipartion of the primary tumor, are now faced with the need to incorpo-rate a great deal of information, and to manage increasingly ... consideredstandard of care for these tumors.Although either multiple Tc-99 injections or a singleintradermal injection over the largest-size lesion hasbeen described, a single periareolar injection of ... thirds compared with standard, single-section analysis of the lymph nodes stained with hematoxylin-eosin. (Adapted from Fortunato L, Amini M, Costarelli L, et al. A standardized sentinel lymph...
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Báo cáo khoa hoc:" Perfluorodecaline residue in the anterior chamber of a patient with an intact crystalline lens: a case report" ppt
... report.Competing interests The author(s) declare that they have no competing inter-ests.Colour images of perfluorodecalin residue in anterior cham-ber of a 17-year-old male with an intact crystalline ... the retina before and after operation. (a and b) Giant retinal tear with shallow detached retina involving the macula in the right eye. (c) Reattachment of retina after vitrectomy.Publish with ... images of perfluorodecalin residue in anterior cham-ber of a 17-year-old male with an intact crystalline lens.Colour images of the retina before and after operationFigure 1Colour images of the...
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Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ