... markers, 288 – 289 Bipolar depressioncharacteristics of, 309–310definition of, 3 08 treatment of, 321–326 Bipolar I disorder phenotypes,definitions of, 13–15 Bipolar offspring, 288 , 289 , 294Bleeding ... random - ized, double-blind, placebo-controlled trial of metformin treatment of weight gain associ - ated with initiation of atypical antipsychotic therapy in children and adolescents. Ameri - can ... 229–231 of conduct disorder, 246–2 48 high risk populations and, 294–2 98 of preschool bipolar disorder, 280 – 284 prevention and, 287 – 288 Pharmacotherapy of comorbid ADHD and maniaas not worsening...