... citation purposes)
Journal of Hematology & Oncology
Open Access
Review
Emerging role of Garcinol, the antioxidant chalcone from Garcinia
indica Choisy and its synthetic analogs
Subhash Padhye
1,2
, ... between chalcone and garcinol moie-tiesFigure 2
A. Structural similarity between chalcone and garci-
nol moieties. B. Formation of chalcone and mig...
... critical and specific role of miR-27 in the regulation
of adipogenic differentiation.
miR-27 prevents the induction of PPARc and
C
⁄
EBPa
In order to delineate the mechanisms by which miR-27
inhibits ... levels of both miR-27a and miR-27b were
significantly increased in the epididymal fat tissue from
the ob ⁄ ob mice, as compared with the genetically
matched lean m...
... the
ligand-macromolecule reaction occured. A binding isotherm
was fitted to the data, expressed in terms of the heat change
per mole of ligand against the ligand to macromolecule
ratio. From the ... affinity are those from the best fit of two sites.
nsd ¼ no site detected. Values are in units of
M
)1
and are the
averages of three measurements. The standard error w...
... the protruding domain consisting
of the type VI b-turn and the first part of b-strand 3Õ (i.e. the
b-hairpin loop and part of the adjoining b-sheet) and
Ôresidues in the loop connecting b-strand ... doi:10.1046/j.1432-1033.2003.03657.x
However, the 9-mer peptide B, CGGWHRLRC, corres-
ponding to the sequence of the MGD1 loop 3 occurring
between the two b-strand...
... His210.
The size of the side-chain at residue 169 and the pK
2
showed a clear linear relationship (Fig. 3B). The pK
2
increased as the size of the residue at position 169 increased.
The effect of the ... supported by the
independency of the ionic strength of the pH-activity curve
(Fig. 5).
In the X-ray crystal structure, the Trp169 side-chain is
located o...
... On the other hand, the fine
and timely analysis of the amyloid architecture of IB
proteins [14,15] has led to the use of these underesti-
mated bacterial aggregates as intriguing models for the
analysis ... Over the last decade, the fine
dissection of the quality control system in bacteria and the recognition of
the amyloid-like architecture of inclusion bodi...
... strongly on
the levels of expression of Adxp but not Adrp and therefore
that the concentration of Adxp is the major factor
controlling pregnenolone synthesis in recombinant yeast.
In conclusion, the ... regulated
similarlyinyeastandinadrenalcells;inthelatter,Adxpand
not Adrp limits the activity of CYP11A1 and hence controls
the extent of pregnenolone production [14]....
... folding
of the protein during the post-translational processing,
and thereby the function of the mature laccase.
Our structural analysis of wild-type MaL indicated
that the last four amino acids of the ... loses its chloride ion
and probably also the T2 copper, as the B-value of the
T2 copper was rather high. On the basis of the anoma-
lous signal, the...
... asthma and atopic
dermatitis [14–17].
In the present study, we further determined the role
of MCP-4 ⁄ CCL13 in RA pathogenesis. We investi-
gated the role of several stimuli on the expression of
MCP-4 ... basal proliferation of RA
FLSs (Fig. 4A). The FLSs from both RA and OA
patients were similar, and we present the data from the
RA-derived FLSs.
Associatio...
... structure of
the ATM–MRN complex should provide further
insight into the molecular mechanism of ATM activa-
tion by MRN and DNA strand breaks.
Conclusion
Although the role of Nbs1 in the ATM-dependent
signaling ... similar to
the ATM-binding domain of Nbs1 are also found in
ATRIP and Ku80 and are required for the interaction
of these proteins with the ATM-relat...