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VASCULAR COMPLICATIONS OF DIABETES - PART 3 potx

VASCULAR COMPLICATIONS OF DIABETES - PART 3 potx

VASCULAR COMPLICATIONS OF DIABETES - PART 3 potx

... with diabetes. Much of our infor- mation on interventions that prevent or retard the vascular complications of diabetes are derived from either sub-group analyses of larger trials, or extrap- olation ... β2-ADR, β2-adrenergic receptor; EP-R, prostaglandin E receptor; VIP-R, vasoactive intestinal peptide receptor; NO, nitric oxide. NO VIP Nitrergic Smooth muscle Vipergic VIP-R K...
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VASCULAR COMPLICATIONS OF DIABETES - PART 10 potx

VASCULAR COMPLICATIONS OF DIABETES - PART 10 potx

... 16 incidence 35 lipid-lowering therapy 43 4 management 40–1 microalbuminuria 38 mortality 19, 35 , 36 , 37 , 38 , 43 obesity 35 , 36 prevention 61–7 prognosis 37 –8, 38 screening 39 statins 43 vascular ... 18, 35 –44 aetiology 36 –7, 37 anti-platelet therapy 43 environmental factors 36 epidemiology 35 –6, 36 and ethnicity 38 –9 evidence-based practice 38 –44 fe...
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VASCULAR COMPLICATIONS OF DIABETES - PART 1 ppt

VASCULAR COMPLICATIONS OF DIABETES - PART 1 ppt

... 4. Vascular Diseases etiology. WK 835 V 330 5 2005] I. Donnelly, Richard, 196 0- II. Horton, Edward S. RC700.D5V375 2005 616.1&apos ;3 dc22 2005008488 ISBN- 13: 97 8-1 -4 05 1-2 78 5-1 ISBN-10: 1-4 05 1-2 78 5-6 A ... and index. ISBN- 13: 97 8-1 -4 05 1-2 78 5-1 (alk. paper) ISBN-10: 1-4 05 1-2 78 5-6 (alk. paper) 1. Diabetic angiopathies. [DNLM: 1. Diabete...
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VASCULAR COMPLICATIONS OF DIABETES - PART 2 pot

VASCULAR COMPLICATIONS OF DIABETES - PART 2 pot

... scale) 10000 1000 100 10 1 0 10–14 15–19 20–24 25–29 35 39 30 34 40–44 45–49 55–59 65–69 50–54 60–64 Age (years) SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES 22 CONCLUSION Risk factors for the micro- and macrovascular complications ... cohort study found a history of MI in 16.5% of males and 9.7% of females at the time of diagnosis of diabetes. During...
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VASCULAR COMPLICATIONS OF DIABETES - PART 4 pot

VASCULAR COMPLICATIONS OF DIABETES - PART 4 pot

... patients with type 2 diabetes (UKPDS 33 ). The Lancet 1998; 35 2: 837 –8 53. SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES 76 SECTION II • DIABETIC NEUROPATHIES 88 pattern of change in PKC ... 977–986. 40 30 20 0 10 60 Conventional Intensive P<0.001 50 0 Conventional Intensive 1 23 348 35 4 4 Year of study 5 32 4 33 5 67 128 136 8 9 79 93 Patients...
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VASCULAR COMPLICATIONS OF DIABETES - PART 5 ppsx

VASCULAR COMPLICATIONS OF DIABETES - PART 5 ppsx

... 1998; 21: 822–827. Study 3 (III-172) 36 44 D’Hemercourt et al. Wounds 1998; 10: 69–75. Study 4 (III-250) 32 36 Smiell et al. Wound Rep Regen 1999; 7: 33 5 34 6. Study 5 (IIIb- 134 ) 57 Embil et al. Wound ... In the Diabetes Control and Complications Trial (DCCT) ‘clinically detectable’ neu- ropathy was found in 39 % of the participants who had type 1 diabetes. In the Epidemiolo...
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VASCULAR COMPLICATIONS OF DIABETES - PART 6 doc

VASCULAR COMPLICATIONS OF DIABETES - PART 6 doc

... with diabetes over the age of 30 is partly due to the difficulty in determining the precise date of onset of disease. The prevalence of retinopathy at the time of diag- nosis of type 2 diabetes ... 837 –8 53. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascu- lar and microvascular complications in type 2 diabetes: UKPDS 38 . BMJ...
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VASCULAR COMPLICATIONS OF DIABETES - PART 7 pptx

VASCULAR COMPLICATIONS OF DIABETES - PART 7 pptx

... No. oedema P Non-proliferative Mild 172 1.7 – 152 2.6 – 126 6 .3 – Moderate to severe 128 20 .3 <0.001 60 36 .7 <0.001 87 63. 2 <0.001 Proliferative 85 69.7 – 26 73. 1 – 35 74 .3 *Percentage ... diagnosis of ischaemia may be difficult in the pres- ence of significant leakage since this obscures the view of the retinal micro- circulation on fluorescein angiograms. Complica...
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VASCULAR COMPLICATIONS OF DIABETES - PART 8 doc

VASCULAR COMPLICATIONS OF DIABETES - PART 8 doc

... products as 3- deoxyglucosone ( 3- DG) and methylglyoxal (MGO). 3- DG is formed by non- oxidative rearrangement and hydrolysis of Amadori adducts and from fruc- tose -3 - phosphate, which is a product of the ... of proteins Polyol pathway Fructose- 3- phosphate Via fragmentation of triose phosphate Glyoxal MGO 3- DG CML GOLD CEL MOLD Advanced glycated end-products In vivo sour...
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VASCULAR COMPLICATIONS OF DIABETES - PART 9 doc

VASCULAR COMPLICATIONS OF DIABETES - PART 9 doc

... (% of control) 150 140 130 120 110 100 0 0 100 110 120 130 140 150 160 170 0 010 -1 1 10 -1 0 10 -9 TPA (M) 10 -8 10 -7 10 -6 n.s 10 20 Glucose (mM) Mannose 30 40 520 mmol Table 21.1 Diabetes- related ... - Retina Rat, canine ↑↑ - II, δ Aorta Rat, canine ↑↑ - Glomeruli Rat, mouse ↑↑ - , - I, - Monocytes Human NM ↑ - II ↑ = increased; NM =...
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