Báo cáo y học: "Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells" pot
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Farnesyltransferase inhibitor treatment restores chromosome territory positions
and active chromosome ... interior (Figure 2.II G-L) and chromosome X remains at the nuclear periphery
(Figure 2.II M-R).
Farnesyltransferase inhibitor treatment restores wild...
... lamin A.
Keywords: chromosome territories, lamin A, Hutchinson-Gilford Progeria Syndrome,
nuclear motors, premature ageing, nuclear myosin 1β, farnesyltransferase inhibitor,
geranylgeranyltransferase ...
interior in proliferating laminopathy cells, including an HGPS cell-line [41]. The X
chromosome remains at the nuclear periphery in all cell cycle states and is located...
... Stress and Psychiatry. In Comprehensive Textbook of Psychi-
atry, 6th Edition Edited by: Kaplan HI and Sadock BJ. Baltimore, Wil-
liams and Wilkins; 1995:1545-1559.
19. Coryell W, Endicott J, Andreasen ... first day, and determination of
cortisol serum levels simultaneously and the next day at
16.00 and 23.00. Cortisol levels expressed in µg/dl were
measured with Luminance Im...
... salivary levels of vasoactive
intestinal peptide (VIP) and neuropeptide Y (NPY), which are
mainly found in parasympathetic and sympathetic nerves,
respectively. This finding indicates increased ... Sorsa T, Konttinen YT: Distri-
bution of vasoactive intestinal peptide (VIP) and its binding
sites in labial salivary glands in Sjogren's syndrome and in
normal controls. C...
... major
phenotypic shift occurs in OA toward a de-differentiated
chondrocyte [40]. Interestingly, in the present study we
observed increased amounts of types I and III collagens by
immunohistology in both ... meniscectomy). Changes in collagen
subtypes in pathological cartilage may not only influence the
biomechanical integrity of the tissue but may sequester and
modulate the acti...
... was performed in culture medium containing
1% heat-inactivated FCS. The monocyte purity and lym-
phocyte purity were assessed by flow cytometry, and fractions
were typically >80% and 90% pure, ... RA synovial T cells and
that their targeting in the clinic has therapeutic potential.
Introduction
A large and diverse range of proinflammatory cytokines and
chemokines have been...
... of inducing other
proinflammatory cytokines and activating matrix metalloprotei-
nases in autocrine and paracrine fashions [2]. Inhibitors of IL-
1 and TNF-α cause a reduction in synovial inflammation, ... HY, Huang HC, Ko CH, Yang LL, Chen YC:
In vitro and in vivo inhibitory activities of rutin, wogonin, and
quercetin on lipopolysaccharide-induced nitric oxide and
prostag...
... 3,3'-diaminobenzidine (Vector Laborato-
ries) containing hydrogen peroxide. The slides were counter-
stained with eosin. The specificity of staining was evaluated by
substituting the primary antibody ... lipopolysaccharide-induced TNF-α expression by
enhancing mRNA decay [19]. Alternatively, 15-LOX products
could prevent IL-1β-induced MMP-1 and MMP-13 expression
by interfering with key...
... functions in phagocytes including induction of
cytokines and chemokines, possibly by collaborating with
TLRs, involvement in endocytosis and phagocytosis and pro-
duction of the respiratory burst ... is
induced in human joint tissues, including chondrocytes and
synoviocytes, by inflammatory stimuli such as interleukin 1β
(IL1β), IL17, and tumor necrosis factor (TNF) [12-20] a...
... that cytokines can be involved in cartilage tissue
or proteoglycan degradation [6]. It has recently been shown in
a serum-containing porcine in vitro model that these cytokines
are able to inhibit ... inhibition by pro-inflammatory cytokines in a serum-con-
taining porcine model. However, in our study most of the
MMP-3 in the culture supernatant was in the pro-form, and it
rem...