... 2009 BioMed Central Ltd
BNIP = BCL2/adenovirus E 1B 19 kDa-interacting protein; C-TAD = carboxyl-terminal transactivating domain; FIH = factor inhibiting HIF; HIF =
hypoxia-inducible factor; HRE ... of
inflammatory cytokines. The HIF transcription factor family
may thus represent an important convergence point in RA,
integrating cellular responses to low oxygen tension and to
inflammat...
... arthritis
being initiated by complement-fixing autoantibodies that
bind to CII in the cartilage matrix [2]. In humans, IgG-pro-
ducing B cells specific for CII are present in rheumatoid
synovium and synovial ... an antibody level of 3 or more.
CB10 and CB11 antibody detection by ELISA
Antibodies against the purified CB peptides of bovine type
II collagen, namely CB10 and CB11, w...
... major proinflammatory cytokines in RA
joints and stimulate IL-6 production by synovial fibroblasts [33-
37], whereas IL-6 is a major circulating cytokine in RA that
induces the acute phase response, ... remarkable efficacy of B- cell depletion in
rheumatoid factor positive RA with rituximab [43] indicates
that B cells are key contributors to the immunopathogenesis
of RA. In...
... anti-citrullinated peptide
antibodies should therefore also be determined. The interac-
tion between HLA-DRB1 genotypes and any new RA gene
established by association and linkage, such as PTPN22
Table ... Pierlot
C, Lasbleiz S, Bardin T, Prum B, Cornélis F: Rheumatoid arthritis
seropositive for the rheumatoid factor is linked to the protein
tyrosine phosphatase nonreceptor 22–620 W all...
... were obtained between October
2005 and February 2006 from patients visiting the rheumatic
outpatient clinic (Clinical Department of Internal Medicine) of
the Innsbruck Medical University (Innsbruck, ... RA is based on the cri-
teria proposed by the American College of Rheumatology
(ACR) in 1987 consisting of clinical symptoms and radiologi-
cal findings, whereas the only laboratory test inc...
... 13-acetate)/ionomycin activated T cells. (a) We detected interferon (IFN)-γ staining but no interleukin (IL)-4 staining. Mul-
tiplex cytokine assay was used to analyse the cytokine profile of three T-cell line ... by intracellular staining/flow cytometry and by
multiplex cytokine bead assay (Bio-Plex). A T-cell proliferative
response to CI was detected in 8 of 25 (32%) SSc patients,...
... GS, Gibson SB, El-
Gabalawy HS: Regulation of apoptosis in fibroblast-like syn-
oviocytes by the hypoxia-induced Bcl-2 family member
Bcl-2/adenovirus E 1B 19-kd protein-interacting protein 3.
Arthritis ... of
inflammatory cytokines. The HIF transcription factor family
may thus represent an important convergence point in RA,
integrating cellular responses to low oxygen tension and to...
... purposes)
infliximab in ankylosing spondylitis [18] and inflammatory
bowel disease [19], but the determining factor in the concen-
tration-effect relation of infliximab is infliximab itself.
Only one ... ATI may have underestimated the infliximab determina-
tion by neutralizing both infliximab paratopes. However, such
undetectable infliximab molecules are inactive and cannot be
taken into...
... Questionnaire in a trial comparing
hydroxychloroquine vs. sulphasalazine. Scand J Rheumatol 1990,
19:407-412.
15. Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I,
Jukema JW, Hyland ... Study Group. PROspective Study of Pravastatin in
the Elderly at Risk. Am J Cardiol 1999, 84:1192-1197.
16. Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I,...
...
appeared
to
respond
mainly
by
walking
upwind.
Hence
this
olfactometer
probably
measures
mostly
mechanical
anemotactic
reponses
(see
K
ENNEDY
,
1977
a).
Wind
shear
forces
in
the ...
ethanol
lines,
and
this
may
obscure
any
role
of
the
ADH
locus
in
olfactory
variation.
An
increase
in
the
frequency
of
ADH-F
has
been
reported
in
other
laborator...