... given autoantibody or immunoglobulin ana-
lyte, synovial/serum index (SSI) was defined as the ratio of
synovial analyte/synovial albumin divided by the ratio of serum
analyte/serum albumin.
Open ... compensate for any effects of rituxi-
mab. More likely, however, and in light of the recent finding that
the size and number of synovial lymphoid aggregates in RA a...
... by the
cross-sectional nature of the analysis, and the discrepancy
may be the result of random variability. Importantly, a single
measurement of inflammatory cytokines is not representative
of ... coro-
nary plaques, thereby precipitating acute thrombosis and
clinical CV events [13]. Interestingly, atherosclerotic plaque
and rheumatoid synovium share an array of infl...
... to
be increased. Both of these results — the effects on the IL-6/
sIL-6R pathway and on IGF-1 in the endocrine system — may
be involved in the mechanisms mediating the beneficial
effects of HRT. There ... significantly in the HRT
group. Furthermore, the change in E
2
in serum was
inversely, though modestly, correlated with the change in
sIL-6R. The change...
... A: Induction by inter-
leukin-7 of lymphokine-activated killer activity in lymphocytes
from autologous and syngeneic marrow transplant recipients
before and after systemic interleukin-2 therapy. ... BL: Morbidity and mortality in
rheumatoid arthritis patients with prolonged and profound
therapy-induced lymphopenia. Arthritis Rheum 2001,
44:1998-2008.
Arthritis Research...
... basis for the prolonged lymphopenia of
CD4
+
T cells after lymphocyte-depleting therapy
specifically of patients with RA in comparison with other
disorders, and report that interleukin-7 (IL-7) ... fibroblast-like
synoviocytes are also relevant in RA pathogenesis and
represented in synovium/pannus [5]. The accessibility of
synovial fluid has permitted the documentati...
... downmodulation of the
inflammation, thereby delaying further tissue damage and
impeding erosive inflammation. These findings might be of
relevance in validating and fostering the development of
clinical ... selectively recruited to and retained
in the rheumatoid joint through interactions involving CXCR4.
In line with the hypothesis that CD4
+
CD25
+
T cells are...
... radiological scores at year (i + 1) versus the
scores year (i) using the differences of year 2 minus year 1, of
year 3 minus year 2, and of year 4 minus year 3; each subject
therefore contributed ... significantly associated with the progression of the
joint space narrowing score over the following year (for exam-
ple, a relative increase of 6.4% in the joint space...
... Ultrasono-
graphic and clinical findings agreed on the presence of signs
of inflammation in 103 joints (21% of the 480 joints) and on
the absence of signs of inflammation in 268 joints (56%). In 91
joints ... joint effusion in any of the examined
finger joints, whereas ultrasonography revealed joint effusion
in 22 out of the 433 examined finger joints.
Si...
... inducing a variety of pro-inflammatory media-
tors, including cytokines, chemokines and other mediators of
bone and cartilage destruction in synovial fibroblasts, mono-
cytes, macrophages and ... modulate
the presence of TH-17 cells in RA.
Introduction
Interleukin (IL)-17 may play a critical role in the pathogenesis
of rheumatoid arthritis (RA). IL-17 is capable o...
... whether circulating plasma cytokine profiles
were associated with clinical involvement in SSc, plasma
cytokines in patients with and without interstitial lung disease,
pulmonary hypertension, SSc ... associated with
alterations in distinct plasma cytokine levels.
Collectively, these data bring to light the complex immun-
opathogenesis of SSc and echo the clinical heterog...