Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
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Vol 10 No 3
Research article
Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk
for rheumatoid arthritis in two longitudinal cohort studies: ... potential interactions between the three polymor-
phisms of interest and the amount and duration of cigarette
Table 4
Effect of PTPN22, CTL...
... polymorphisms within genes
and the analysis of multiple genes within pathways.
The effects of polymorphisms are best represented by
their haplotypes. Data from multiple polymorphisms
within a gene ... common polymorphisms in
DNA repair genes are continuously being identified,
and these polymorphisms may play a pivotal role in
sporadic carcinogenesis. A growing body...
... Huang YK, Chen YT, Hsueh YM: Urinary
8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic
exposure area. Toxicol Appl Pharmacol 2008, 226:14-21.
19. Huang YL, Hsueh YM, Huang YK, Yip ... of the data in the study and take
responsibility for the integrity of the data and the accuracy of the data
analysis. Study concept and design: CJC, LIH. Acquisition of...
... were white and
continued to smoke during the 5-year period of the LHS.
These subjects were genotyped for polymorphisms in α1-
antitrypsin, mEH, vitamin D binding protein, and TNF-α and
TNF-β genes. ... pitfall of studying polymorphisms in candidate
genes, however attractive, chosen based on a limited
understanding of the pathophysiology of disease.
Chronic obstructive...
... cardiovascular, and renal dysfunction a nd
for the pulmonary, hematologic, and hepatic systems
and address both the relative severity among organ sys-
tems and the degree of severity within an organ system.
The ... (University Hospital of Muenster, Germany) and
from the intensive care information system COPRA 5.2
(COPRASYSTEM GmbH, Sasbachwalden, Germany),
which is interfaced...
... combined with no previous
events, or 2) a past history of LBP and gradual worsening with treatment. Indications for MC were a good outcome
combined with a previous history of low back pain between ... is being conducted in
the Nordic countries trying to illuminate the use of, the
indications for, and the efficiency of MC. So far, it has
been determ ined, that there is a...
... effective in the prevention of NSAID ulcers than low-
dose H2RAs [5]. However, the efficacy of PPIs and H2RAs in
the primary prevention of clinically relevant endpoints, such as
bleeding and perforated ... significantly with regard to the
number of risk factors for NSAID-associated gastropathy, sug-
gesting comparable risk profiles. Similarly, in a post hoc sub-
grou...
... (range,
32–66) years, the functional requirements of the injured
hands of the patients participating in our study being
highly " ;in demand" prospectively as regards these individ-
uals' working ... diameter, and availability without producing a
deformity. This choice of technique for tendon grafting fea-
tures the advantage of the source of donor tendon being
r...
... exocrino-
pathy in the NOD mouse and by reducing one of these regions
considerably, Nguyen et al. in a recent issue of Arthritis Research
and Therapy propose candidate genes for development of
Sjögren’s ... hereditary and environmental factors. The
disease is characterized by lymphocytic infiltration and inflam-
mation in the salivary and lacrimal glands, leading to...
... homeostasis and joint
pathology. About 35 were identified with very varied support-
ing evidence, including some with a putative protective effect.
We looked for evidence of single nucleotide polymorphisms
(SNPs) ... recipient of a scholarship of the National Program for the Training
of University Professors of the Spanish Ministry of Education. AG was
supported by...