Báo cáo y học: "Metabolic syndrome in rheumatic diseases: ep

Báo cáo y học: "Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications" doc

... the insulin receptor and/ or IRS proteins, whereas the MAP kinase pathway remains open and may even be hypersensitive [10]. Inflammatory cytokines and insulin resistance Inflammatory cytokines ... [8]. Pathophysiology: complementary roles of insulin resistance and abdominal obesity Insulin signaling Since insulin resistance is a key feature of this syndrome, a brief overview of insuli...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: "Vascular involvement in rheumatic diseases: ‘vascular rheumatology" pps

... joint, are characterized by enhanced accumulation of inflammatory monocytes/ macrophages and T cells. These inflammatory leukocytes abundantly produce proinflammatory cytokines, chemokines, and ... weakly adhere to the endothelium lining the inner vessel wall (tethering) followed by rolling of leukocytes on the endothelial layer. Tethering and rolling are mediated primarily by selectins...

Ngày tải lên : 09/08/2014, 13:22

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Báo cáo y học: "Gender difference in QTc prolongation of people with mental disorders" docx

... of QTc prolongation in psychiatric patients in various inpatient and community settings and found that age over 65 years, use of tricyclic antidepressants, thioridazine, and droperi- dol were ... / day) among patients taking each cluster of psychotropics were 435 (545) mg and 73.9 (75.1) mg, respectively. Since atypical antipsychotics (AAPs) were approved in 1996 by the Min- ist...

Ngày tải lên : 08/08/2014, 20:23

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Báo cáo y học: "Transcription profiling of rheumatic diseases" doc

... limit consistency of study results. For example, variability in the amount and quality of starting RNA; amplification and labelling strategies employed; and dyes, probe sequences and hybridization ... associated with clinical readouts, we could select the clinically useful molecular markers and apply these in routine clinical practice. In addition, these data may help to e...

Ngày tải lên : 09/08/2014, 01:22

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Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps

... RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines (TNF-α, ... progressively failing myocardium) fashion, contributing to subclinical and eventually clinically recognizable ventricular dysfunction (Fig. 1). Inflammatory pathways and myocardia...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx

... cartilage degradation and by activating pro-inflammatory mediators based on its in vitro reactivity [8,9]. However, MMP2 levels and activity seem to be unaltered in human RA [35-37] and in experimental ... support to this hypothesis and will show how important it is to define the participation of each ECM protease in joint pathology before trying to manipulate them therapeutic...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect" ppsx

... results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this compound. Moreover, in this trial, a statistically ... lipooxygenase inhibitor but also, at a lower magnitude, an inhibitor of the TNFα-induced gene expression of matrix metalloproteinases. Such in vitro findings have to be kept in...

Ngày tải lên : 09/08/2014, 11:20

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Báo cáo hóa học: " Septic AKI in ICU patients. diagnosis, pathophysiology, and treatment type, dosing, and timing: a comprehensive review of recent and future developments" doc

... used, including cystatin- C, Neutrophil gelatinase-associated lipocalin (NGAL) in the serum and urine, IL-18, and kidney injury molecule 1 (KIM -1) [34-36]. Type of therapy in a general ICU setting CRRT ... otic-inflammatory AKI, the administration of caspase inhibitors (CI) gains increas- ing interest. Indeed, CI ameliorate ischemia-reperfusion injury in different organs, including...

Ngày tải lên : 21/06/2014, 01:20

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Báo cáo y học: " Primary Prevention of Allergic Diseases: Current Concepts and Mechanisms" pps

... family of imidazoquinolina- mines, inhibits allergen-induced Th2 responses, airway inflamma- tion and airway hyper-reactivity in mice. Clin Exp Allergy 2004;34: 1314–20. 18. Bian T, Yin KS, Jin ... via endocytosis; they bind and activate cytosolic TLR-9 and induce activation of NF- kB, followed by secretion of type I interferons, IL-12, IFN- inducing protein 10, and other cytokines...

Ngày tải lên : 08/08/2014, 21:20

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Báo cáo y học: "Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions" doc

... hereditary angioedema. Effects of sex hormones on bradykinin pathways, and contribution to clinical phenotype Before considering the influence of the sex hormones on key enzymes if bradykinin pathways, ... that symptoms occurred during normal estrogen states. Attenuated androgens act at many points in bradykinin pathways to favour lo wer levels of bradykinin, thereby ameliorating sympto...

Ngày tải lên : 08/08/2014, 21:20

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