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Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy" pps

Báo cáo khoa học:

Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy" pps

... Role of mitomycin in combination with fluorouracil and radiotherapy, and of sal-vage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of ... Hennequin C, Gornet JM, Furco A, Gerard L, Lemann M,Maylin C: Anal carcinomas in HIV-positive patients: high-dosechemoradiotherapy is feasible in the era of highly active antiretroviral therapy. ... RJ, Huber PJ, SimmangCL: Outcome of HIV-infected patients with invasive squa-mous-cell carcinoma of the anal canal in the era of highlyactive antiretroviral therapy. Dis Colon Rectum 2004,47(8):1305-1309.49....
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Báo cáo khoa học: Amyloid oligomers: formation and toxicity of Ab oligomers ppt

Báo cáo khoa học: Amyloid oligomers: formation and toxicity of Ab oligomers ppt

... M (2004)Kinetics and binding sites for interaction of the prefol-din with a group II chaperonin: contiguous non-nativesubstrate and chaperonin binding sites in the archaealprefoldin. J Biol ... prion disease, the interaction between the Ab oli-gomer and the prion does not require the infectiousPrPScconformation. This interaction may disrupt the interaction between PrPC and a co-receptor, ... changes in the monomer in solution, whichcan be evaluated from the frequency of noncoincidentmonomer bursts. Experimental data suggest that the stability of the SH3 domain of the phosphatidylinosi-tol...
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Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt

Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt

... proteins producetoxic oligomers and interact with other proteins. The improvement of microscopic techniques will promote the understanding of the dynamics and toxicity of mis-folded proteins in ... FRAP analysis of HSP70–YFP in Huntingtin-150Q–CFP inclusions revealed that HSP70 is mobilewithin the inclusion [20]. As the movement of HSP70 issignificantly slower in the inclusion than in the ... aggregation of polyQ-expanded proteins or ALS-linked SOD1 in vivo.Conclusions and perspectivesWe reviewed the dynamics and toxicity of misfoldedproteins (including polyQ-expanded proteins and ALS-linked...
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Báo cáo hóa học:

Báo cáo hóa học: " Research Article Existence and Multiplicity Results for Degenerate Elliptic Equations with Dependence on the Gradient" docx

... Ω. Then there exists C = C(N,m,λ) (independent of R)such thatinfB(·,R)u ≥ CR−N/λB(·,2R)uλ1/λ. (2.3) The following lemma al lows us to control the parameter τ in the Blow-Up analysis.(See ... to the problem−Δmu = λfx, u+,∇u+−a(x) gu+,∇u+ in Ω,u= 0on∂Ω.(3.6)Multiplying (3.6)byu, integrating over Ω the equation obtained, and applying H¨older’s and Poincare’s ... S1−(θ+1)mnτn.(2.31)Arguing as in the proof of Claim 3 in the above case xn∈ ∂Ω0for all n,wemayassumethat δnSnθ ≥ d0= d0(p, α,β,N,c0) > 0. Therefore, the limit w of the sequence wnsatisfies−Δmw(y)...
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Báo cáo khoa hoc:

Báo cáo khoa hoc:"Multiple trait model combining random regressions for daily feed intake with single measured performance traits of growing pigs" pdf

... bymeans of Cholesky decomposition and backsubstitution when generating newsolutions in the Gibbs sampler. The data was analysed including (model 1) and excluding (model 2) “weight at the end of the ... for the period between the start and the end of the test, as well as carcass lean content and meat quality index determined after the slaughtering of tested animals.2.2. Model The following random ... of daily feed intake increased from 0.20 in the first week of the testingperiod to 0.38 in week 10 (Fig. 1), which is in the range of the values reportedby other authors [4–6, 14]. Because of...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf

Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf

... Global segment interactions and the folding profiles in wild-type SNase. (A) W140, in loop 1 interacts with loop 2 and loop 3which forms a ‘lower neck’ network area in maintaining protein ter-tiary ... role in maintainingSNase tertiary structure.Our CD and DSC data show that the W140 in SNase is the amino acid responsible for the stability of the whole protein. However, in comparison with the wild-type ... SNase.Changes in the fluorescence intensity of W140 reflecta change in the hydrophobic environment surroundingW140 and thus indicate a change in the overall (ter-tiary) structure of the protein. Figure...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Subgrammars, Rule Classes and Control in the Rosetta Translation System" ppt

... specifies 1. the meaning of the basic expressions (basic meanings). 2. the meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta ... that the place of this subdivision coincides with the 'switch point'. There is another argument for making this sub- division: the first part of the control expression of the subgrammars ... for the compositional and the analytical definition of a language. This is proved by the formal definitions in subsection 6.2. The third problem concerned the consequences of defining the...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt

Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt

... from the Protein Data Bank. The circled areas show local stable segments: interactions of G75 with H121 and K9, and of G129 with K110 and K133. Other chargedamino acids such as D73, D83 and E101 ... forces to the areas surrounding the interactions with E75 and E129. Privalov and coworkers reported the presence of noncovalent bonding, including an electrostatic bondbetween E75 and H121, and a ... exists in these mutants (Fig. 1).Thermal analysis of protein unfoldingThermal denaturation determined by DSC was used tomeasure the stability of the mutant proteins. Based on the measurements of...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx

Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx

... of analogs in the active center. Furthermore,these findings also seem to indicate that the analogs canFig. 5. Scheme of the HDC reactions with the natural substrate histidine and the histidine-analogs ... covalentbinding of the adduct to the catalytic center could fix somesecondary structure in the enzyme, suggesting severalinteraction points for the adduct within the catalytic center in addition ... 5 min, the spectra of the HisOMe -treated samples had stabilized with the 390-nm peak as the major and final one. In the reaction in the presence of an excess of the natural substrate histidine,...
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Báo cáo khoa học:

Báo cáo khoa học: "Local and Global Algorithms for Disambiguation to Wikipedia" pot

... conceptbased on the counts in P (t|m).4.5 Linker and Ranker TrainingWe train the coefficients for the ranker features us-ing a linear Ranking Support Vector Machine, usingtraining data gathered from ... Wikipedialinks are considered gold-standard links for the training process. The methods for compiling the Wikipedia training corpus are given in Section 5.We train the linker as a separate linear ... attractive trade-off of accuracy and efficiency. The last column of Ta-ble 2 reports the number of solvable mentions and the corresponding number of titles with a cutoff of 20 disambiguation candidates,...
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