Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx

... Division of Rheumatology and Immunology, Stanford University School of Medicine, Stanford, California, USA2Department of Neurology and Neurological Sciences, Stanford University School of Medicine, ... believe the specificity of the autoantibody response is predictive of the speci-ficity of the overall autoimmune response at the level of whole autoantigens. Further studies will be necessary todetermine ... arraysReviewAutoantibody profiling for the study and treatment of autoimmune diseaseWolfgang Hueber1, Paul J Utz1,3, Lawrence Steinman2,3 and William H Robinson1,2,31Department of Medicine,...

Báo cáo Y học: Structural basis for the inhibitory efﬁcacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

... 4 the binding modes of the three inhibitors aresuperimposed in the mutant NNIBP. The cyclopropyl-group of MSC194 and the methyl group of PNU142721partly overlap the trifluoromethyl group of ... plane of the thioureamoiety and the Ca of G190.Hence, the undefined orientation of the N103 amide Od1 and Nd2 atoms may r eflect the repulsive forces exerted on the inhibitors.Other factors of ... namely that they contain ahydrogen-bond donor in wing2. This property is of generalimportance for the efficacy of the inhibitor. Substitution of the hydrogen-donating amide group for a methylene...

Báo cáo Y học: Amyloid-ﬁbril formation Proposed mechanisms and relevance to conformational disease docx

... Lewy bodies and in the Lewy bodyvariant of Alzheimer’s disease [17]. a-Synuclein is the maincomponent of the Lewy bodies [18]. Both a-synuclein and synphilin are required for formation of the ... possibly, formation of amyloid fibrils.It is a matter of debate as to whether the fibrillaraggregates and amyloid plaques are the side-product of some other pathology or whether they are the main ... A˚. Type 1 fibrils are thinner and are formed from one filament only. There are other types of fibrils [62]; for example, a fibril and untwisted filaments of human stefin B [31] (type I cystatin)...

Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"

... result in the uncertainty of the strategy for its treatment. While further delineati n g the clinicopathological and radiological features, and summarizing the surgical therapy strategy of this ... analysis of sol-id-pseudopapillary tumor of the pancreas: report of 15 cases. Hepatobilliary Pancreat Dis Int. 2008;7(2):196-200. 10. Yu CC, Yeh CN, Hwang TL, Jan YY. Clinicopathological study ... experience with the management of disseminated disease is very limited in the literature6, therefore, attention to the therapy strategy of this neoplasm in the future may allow a more reasonable...

Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx

... findings.Together, these results demonstrate the impact of large-scale gene expression profiling on the analysis of distinctT lymphocyte populations. The analyses of the expression of 6000 genes ... expressionanalysis of T lymphocytes, the key players in severalinflammatory diseases, and on the microarray analysis of brain tissue from patients with multiple sclerosis (MS). The identification of novel ... expression profiling has an increas-ing impact on immunology and, in particular, on the char-acterization of immunological diseases. This profiling technology can reveal the physiology of cells and...

Báo cáo y học: " Exercise therapy for the management of osteoarthritis of the hip joint: a systematic review" pot

... Score; and/ or the pain subscale of the Health Related Quality of LifeTable 1Level of evidence for evaluating the efficacy of exercise therapy in the management of osteoarthritis of the hipLevel of ... solely on hip joint OA and todecide whether they met the recommendations of the guide-lines highlighted earlier, and also to determine the efficacy of their exercise-therapy interventions for ... considered the con-sistency of findings across studies, the design of the studies(e.g., RCT, pre- and post-design) and the quality level of the studies. These criteria allowed the categorization of...

Báo cáo y học: "Vertebrates used for medicinal purposes by members of the Nyishi and Galo tribes in Arunachal Pradesh (North-East India)" pdf

... by members of the Irular, Mudugar and Kurumbar tribes of the WesternGhats of Kerala [60]. Except for the Ao Naga of Naga-land [49] and the Nyishi and Galo of Arunachal Pradesh the use of the ... withleucoderma by the tribes of Kerala [60]. The Mompa of Arunachal use the fat of the crow incases of smallpox and malaria [27]. Members of the Nyishi and Galo tribes use the gall bladder of the mithun ... es of Andhra Pra-desh, Kerala, and the Ao Naga of Nagaland use the same material to improve the overall vitality of a person and the fat of this reptile to treat rheumatism and pains of the...

Báo cáo y học: "Normative values for the Foot Posture Index" ppt

... longitudinalarch and the extent of abduction/adduction of the fore-foot on the rearfoot [12]. The concurrent validity of the FPI has been investigatedfully and reported previously [12]. A more recent study has ... the extent of the inversion/ever-sion of the calcaneus. The observations of the forefootconsist of assessing the bulge in the region of the talo-navicular joint, the congruence of the medial ... classifying foot type for the purpose of research and clinical decision making.BackgroundVariations in foot posture are thought to influence the function of the lower limb and may therefore play...

Báo cáo y học: "Clinical guidelines for the recognition of melanoma of the foot and nail unit." doc

... malignantmelanocytes within the basal layer of the epidermis, giv-ing rise to the term “lentiginous”.Theterm“acral”defines the location which is of the extremities, namely the skin of the hands and feet, ... the hands and feet. In the early stages, the clini-cal symptoms for this type of melanoma mayb e verysubtle such as an ill defined macule or patch of lightbrown or grey discolouration of the ... by potassium permanganate. This can bedemonstrated by scraping the surface of the nail. Wherethere is onycholysis, the same may apply to the undersur-face of the nail. This is particularly...

Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"

... aspirin was only 3.5. But, we think sin-gle antiplatelet therapy may be less effective for the secondary prevention of stroke than the combination of antiplatelet and anticoagulant therapy. We have ... noted in the single antiplatelet therapy group, and one subcutaneous hemorrhage was found in the combination therapy group. As for the patient in the single antiplatelet therapy group who ... warfarin treatment was no more effec-tive than moderate-intensity treatment in preventing recurrent thrombotic events. The APASS study [3] was the first prospective study of the role of aPL...

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