Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... syndrome and alter the course of established disease. These data suggest thatautologous T cells primed and expanded with TGF-β have the potential to be used as a therapy for patients with systemic ... systemic lupus erythematosus and other chronic inflammatory diseases. This noveladoptive immunotherapy also has the potential to prevent the rejection of allogeneic transplants.Keywords: autoimmunity, ... generate sup-pressor T cells ex vivo in large numbers, and raises thepossibility that the transfer of these cells back to the donorCommentaryThe potential of human regulatory T cells generated...
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Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx
... manifestations.The association of CD4+CD28– T cells with diseasestatus has given rise to the hypothesis that these cells directly contribute to disease manifestations. Patients withnodulosis and extra-articular ... functionally active and have the ability torelease cytokines in the absence of a costimulatorypathway.CD4+CD28– T cells contribute to the cell infiltrate and exhibit increased survival after ... correlation betweenthe CD4+CD28– T- cell subset and extra-articular manifes-tations, magnitude of joint involvement, and presence of rheumatoid factor.Material and methodsPatientsForty-two...
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Báo cáo y học: "Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity" ppt
... participated in study design, and coordinated acquisition of clinical data and laboratory samples, as well as entry of clin-ical and laboratory variables into the database. All authors par-ticipated ... statistical analyses. TM and JOC coordinated the acquisition of laboratory samples,clinical data acquisition, and entry of clinical and laboratoryvariables into the database. TJH, CMTG, and GSC partici-pated ... measured IgG ANAs,using HEp-2 cells as a substrate. The frequency of ANA posi-tive status at the time of study in our lupus patients was85.2%, as compared with a rate of 4% ANA positivity...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... induction of a population of Treg and documentation of their in vivo potential was an importantnext step. In pursuit of this goal, recent studiesdemonstrated for the first time that the transfer ... Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA2Mucosal Immunology Unit, Oral Infection and Immunity ... and regulationTGF-β is a potent cytokine and growth factor whosebiological activity is primarily regulated post-translationally[30], because it is transcribed and translated as a smalllatent...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... was ampli®ed by PCR from the TriplEx cloneby using Pfu DNA polymerase (Stratagene) and theupstream primer (5¢-TTTTTTCTCGAGAAGCTTTCCCTGCAGGAT-3¢) and downstream primer (5¢-TTTTT T GGATCCCTACAGATGTGCTTCAAGGCC-3¢), ... he amount of product released in testincubations. For estimations of the apparent af®nity (Km) and kcat, steady-state rates were determined over a range of substrate concentrations (at least ... spectrophotometric ally at 400 nm. For each substrate, d ata were obtained at various concentrations under steady-state conditions, and the data ®tted to the Michaelis±Menten eq uation in orde r to obtain estimates...
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Báo cáo Y học: Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway pot
... oligonucleotides of 5¢-GCAGCAAATGAGCCCAGGTACACCTGTTCC-3¢ and 5¢-GGAGGGCACCCACATGTTCCCATGC-3¢ were used as the forward and reverse primers. Similarly, oligonucleotides of 5¢-AAGTATAACTCTCGAGCCCTCCACATCAAGG-3¢ ... us with anotherimportant enzyme target in the topoisomerase I pathway for therapeutic intervention.TDPwasfirstnotedasanenzymeinyeastwithactivitythat specifically cleaves the phosphodiester bond ... containingprotease inhibitor cocktail and lysed by sonication. Aftercentrifugation, the supernatant was loaded onto a DEAE-Sepharose column, and eluant containing His-tagged yeastTDP was then...
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... with significant increases in both bone for- mation rate and mineral apposition rate in the tibiae of ratstreated with cerivastatin at 0.1 mg/kg/day. Statins, there-fore, have the potential to ... 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc-tase enzyme. These include naturally occurring lovastatin,chemically modified simvastatin and pravastatin [1–3] and the synthetically derived atorvastatin, ... fluvastatin and cerivastatin. All of these agents are widely used for lower-ing cholesterol, and they provide an important and effec-tive approach to the treatment of hyperlipidemia and arteriosclerosis...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... 5' ATT TCT GGC TTC TAG TCT GGT GTT C 3'5' ACT TGA TTT CAG GTC AAT AAC GGT CCC C 3'5' AAC GTG CCA GTG TGG AGT GA 3' 0.163MMP-3 5' TGA AGA GTC TTC CAA TCC ... TCC TAC TGT TG 3'5' CGT GGC AGT TTG CTC AGC CTA TCC AT 3'5' CTA GAT ATT TCT GAA CAA GGT TCA TGC A 3'0.108MMP-9 5' CCC GGA GTG AGT TGA ACC A 3' 5' ... CAT GTT 3'5' CTT TTG CCG GTG TAG GTG TAG ATA G 3'0.108ADAMTS-4 5' ACT GGT GGT GGC AGA TGA CA 3' 5' ATG GCC GCA TTC CAC GGT G 3' 5' TCA CTG TTA GCA...
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Báo cáo y học: "κ The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis" ppsx
... receptor; TRAF, TNFreceptor-associated factor.Intact upstream activators of the classical and alternativepathways of NF-κB are also essential for normal lymphoidorganization and establishment of self-tolerance. ... [1-6].These pathways are termed the ‘classical’ or ‘canonical’pathway and the ‘alternative’ or ‘noncanonical’ pathway.The classical nuclear factor-κκB pathwayIn the classical or canonical pathway ... RANKL.ConclusionBoth classical and alternative pathways of NF-κB activationregulate survival and activation of T and B lymphocytes attheir sites of development in thymus, bone marrow and spleen, and in the...
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Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies" pptx
... features of thepharmacophore model used as the 3D query in datab asesearching was retai ned as a hit. Two database searchingoptions such as Fast/Flexible and Best/Flexible searchare available ... hypothesis and the total cost.The larger the difference between the cost of the nullhypothesis and total cost, the greater the likelihood thatthe correlation between the fit values and actual ... improve the ability to identify and optimize hits and confirm their potential to serve as scaffolds for producing new therapeutic agents.In this study, we developed both qualitative and quanti-tative...
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Từ khóa: flow cytometric detection of human regulatory t cellsbáo cáo y họcbáo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenanalysis of the methylome of human embryonic stem cells employing methylated dna immunoprecipitation coupled to next generation sequencingnod scid mice bone marrow on the frequency of human hematopoietic stem cellstgfβ on the growth of human myeloid leukemia cellsclinicians employers policymakers and others make informed decisions about the provision of health care services this report is intended as a reference and not as a substitute for clinical judgment2 rationale for the delivery of antineoplastic agents by the intraperitonealroute as a treatment for intraperitoneal malignanassessment of suppressive capacity by human regulatory t cells using a reproducible bi directional cfse based in vitro assaycd4 t cells their hla dr expression and the proportion of gag specific t cells in blood and mucosal sites of controllerspublic investment projects shall be prepared implemented and monitored in the framework of decree law no 540 dated 19 6 1994 investment program preparation guide and other relevant legislation provisionsMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ