Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... transcription of an array of inflammatory genes, their
direct regulation of MMP transcription is just beginning to
be elucidated. In the remainder of this review, we address
how these pathway-specific ... arthritis: integration of complex signaling pathways for
the recruitment of gene-specific transcription factors
Matthew P Vincenti
1
and Constance...
... target
genes at different developmental stages. Therefore, the
interplay among the various transcription factors involving
their stage of expression, type of cells expressing them, the
combination of ... implications for the interactions among the
transcription factors.
Many of the erythropoietic transcription factors are
complex, multidomain proteins. Different...
... motifs using Scansite [23]
predicts a high-stringency target site for phosphorylation
by protein kinase C-ε (PKCε) within the amino-terminal
region of KLF17. Given that the activity of some ... might play a role in the regulation of
invasion and metastasis in different cancer types.
Figure 1
Regulation of ID1 expression by KLF17. ID1 transcription is suppressed b...
... on the basis of the intensity
value for the PCR product on the gel (as assessed by the
IPLab Gel software) relative to the intensity value for the
676-bp band in the molecular mass standard.
The ... the type of inflammation seen in mtDNA-injected
mouse joints. It is also worth emphasizing that the process
of inflammation in RA joints is dynamic, with the...
... ethnic minority area.
Materials and methods
Study area
The present study was undertaken in Gongshan County,
NW Yunnan of China. The County is situated in the
northwest end of Yunnan province, between ... equally during the field work, data analysis and
preparation of the manuscript, and read and approved the final manuscript.
Competing interests
The authors declare tha...
... effective in inhibiting the activity of purified recombin-
ant MTE-I in an in vitro assay performed in a Hepes-based
buffer containing only KCl. Information about the tertiary
structure and of ion ... activity of the enzyme (data
not shown).
NDGA is known to inhibit the activity of lipoxygenase
by binding to the reduced form (Fe
2+
)oftheenzyme
thereby keeping it inac...
... cells. A very rapid increase of
the hydA transcript was detected in the first 3 0 min of
anaerobiosis. This quick increase of gene transcription is
only reported for the cyc6 gene in C. reinhardtii ... that the induction of the anaerobic
proteins is the result of a n increased mRNA level. Maize
(Zea mays L.) responds to anaerobic stress by redirect-
ing t he synth...
... desferrioxamine biosynthe-
sis is the decarboxylation of lysine by a lysine
decarboxylase encoded by the desA gene [8,9]. Lysine
decarboxylases occur in different Streptomyces species
and are involved in ... source, indicating that the encoded lysine
decarboxylase is a dedicated enzyme committing
l-lysine to the desferrioxamine pathway, as occurs with
p-aminobenzoic acid synthas...
... participating in both the immediate-
early transcriptional response to infection and the secondary
response to cytokines [3–5]. For instance, IFN-b synthesis is
activated directly by virus infection in ... systematic
analysis of the role played by the two sets of Ser/Thr
residues in the virus-dependent activation of IRF-3. To this
end, we examined the phenotypes of...
... activity was
dramatically diminished. Alternatively, hTR and hTERT
may play a minimal catalytic activity in telomerase, while
the assembly of other telomerase subunits may amplify the
enzyme function. ... morphology after
induction of differentiation of HL-60 cells by
dimethylsulfoxide and TPA. (A) HL-60 cells
cultured in RPMI for 3 days (control for B),
followed by cytospin...