Báo cáo y học: "Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice" pptx
Báo cáo y học: "Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice" pptx
... we investigated the effects of leptindeficiency on zymosan-induced arthritis (ZIA), which isindependent of adaptive immunity. Arthritis was induced byinjection of zymosan into the knee joint. ... joint swelling in zymosan-induced arthritis Arthritis was induced in ob/ob and control +/? C57BL/6mice by injecting zymosan A into the right knee joint. Toassess whether leptin deficiency ... inflammation has recently become increasingly evident.The increase in leptin production that occurs during infec-tion and inflammation strongly suggests that leptin is a part of the cytokine cascade,...
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Báo cáo y học: "The determinants of susceptibility/resistance to adjuvant arthritis in rats" ppt
... T-helper type 2 shift and increase thesecretion of anti-inflammatory cytokines IL-10 and IL-4, whiledecreasing the secretion of proinflammatory cytokines TNFαand IL-1 [53]. This change in cytokine ... significantly [19].Interestingly, inhibition of monocyte chemoattractant protein 1after the onset of AA downmodulates the course of AA,highlighting the significance of the role of this chemokine in the ... different kinetics of entry into and accu-mulation within the target organ (the joints), with an increasednumber of cells retained therein in LEW rats correlating withAA susceptibility.Increased...
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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... outside hospitals in Norway. Emergencymedicine is not a formal speciality for doctors in Norway.Still, treatment of critically ill or injured people is definedas emergency medicine. Earlier white ... municipality withapproximately 4 000 inhabitants found an incidence of 27medical emergencies per 1 000 inhabitants per year [7].However, the definition of an emergency was wider in thisstudy than ... proportion of 45% (table 4).A29 “Breathing difficulties” was the most used Index-category in the “all other” group with nearly 5% of thetotal. Approximately half of all patients in the youngestage...
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Báo cáo y học: "A Comparison of Immuncapture Agglutination and ELISA Methods in Serological Diagnosis of Brucellosis"
... presump-tive diagnosis of brucellosis which were sent to Cen-tral Microbiology Laboratory of Selcuk University Meram Faculty of Medicine from various clinics were included in the study and kept at ... analyzed by using the paired t test method on SPSS for Windows 13.0 software. This study was approved by the local institutional ethics committee of the Selcuk University Meram Faculty of Medicine. ... possible to determine the type of antibody (3). Obtaining negative results in agglutination tests is a common phenomenon. One of the reasons for this is blocking antibodies. One of the methods...
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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"
... in at least 10% of invasive carcinoma cells or presence of mem-branous staining in less than 30% provided that the staining is intense (++) Score 3: Presence of intense staining surrounding ... Training and Research Hospital 1st Biochemistry Clinic 3. Dokuz Eylül University Institute of Oncology 4. İzmir Atatürk Training and Research Hospital 1st Pathology Clinic Corresponding ... studied in terms of tumoral development and inflammatory response rather than malignancy. Another study by Mathelin et al. included a total of 89 patients. Bc1a and Bc1b defined by the authors...
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Báo cáo y học: "Comparative study of serum Na+ and K+ levels in senile cataract patients and normal individuals"
... associate professor in Department of Ophthalmology, Iran University of Medical Sciences, with research interests in epidemiology in ophthalmology. Issa Nourmohammadi obtained BSc (Chemistry) from ... University, Oklahoma, in 1976, MSc (Biochemistry) from University of Oklahoma in 1978, and PhD (Nutritional Biochemistry) from University of Arizona in 1981. He is currently an associate professor in ... Department of Biochemistry and Nutrition in Iran University of Medical Sciences. He is interested in study of nutrition and trace elements in human blood. Manuchehr Imamian obtained BSc in Chemistry...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... (naringin)Hesperetin-7-GlcRha (hesperidin)Dihydrochalcones Phloretin-7-Glc (phlorizin)Secoiridoids OleuropeinAnthocyanidins Cyanidin-3-Glc (kuromanin)Cyanidin-3,5-diGlcFig. 4. Structure s of ... 4NP-b-D-glucopyranoside (10 mM) was reduced by 98% in thepresence of 4NP-b-D-mannopyranoside (10 mM)].Hydrolysis of xenobiotic glycosides by reCBGThe a bility of CBG to hydrolyse a variety of glucosides ... (1997) The crystal structures of Sinapis alba myro-sinase and a covalent glycosyl±enzyme intermediate provideinsights into the substrate recogn ition and active-site machinery of an S-glycosidase....
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Báo cáo Y học: Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile pdf
... toxin in either gluco-syltransferase or glucosylhydrolase reactions. Using a com-petition assay, the affinity of UDP-Glc was determined to be45±10 lM in the absence of Mg2+. The binding of ... Mg2+affinity regardless of the TcdA concentrations, as the metalbinding event would be totally independent of the interac-tions involved in the enzyme–substrate complex. Thebinding of MUG and ... moiety of MUG makes several good hydrogen bonding interactionswith positively charged arginine groups (R191, R195 andR269) in the minimized structure, thereby stabilizing thenegative charge of...
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Báo cáo Y học: Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 1003 potx
... amounts of sialylated Hex3 glycoforms were indicated.bMinor amounts of Hex2 and Hex3 glycoforms lacking acetyl groups orcontaining a second glycyl group were indicated.cVery minor amounts of ... 12 : 32 : 25. Methylation analysis of dephosphory-lated O S-1 showed significantly increasing amounts of terminal Glc and 2-substituted Hep, thereby indicatingphosphorylation of these residues ... PChoÆAc1)3ÆGly1ÆHex3ÆHep3ÆPEtn1ÆAnKdo-ol. Minoramounts of Hex2 and Hex3 glycoforms lacking acetylgroups or containing a second glycyl group were alsoindicated (data not shown). I n addition to the m ajorHex2 and Hex3 glycoforms,...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... used flow cytometry to determine cell cycle progres-sion by quantifying DNA. Effects of inhibition of c-Myc tran-scriptional activity and inhibition of ERK1/2 activity in thepresence of 5 ng/mL ... degradation of c-Myc byphosphorylation of the serine 62 residue in the N-terminal of c-Myc [24]. They also found that the suppression of glycogensynthase kinase 3 beta (GSK-3) activity, which ... possibility of involvement of the MAPK pathway in regulation of c-Myc sta-bility, we devised serial experiments using the pathway spe-cific inhibitors 10058-F4, an inhibitor of c-Myc transcriptionalactivity,...
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