... Th1 = T helper type 1; TNFα = tumor necrosis factor α.
Arthritis Research & Therapy Vol 6 No 2 Schramm et al.
Research article
Susceptibility to collagen-induced arthritis is modulated by ... in arthritis
development [3]. However, little is known about the regu-
lation of T cells that leads to the maintenance of immune
homeostasis within the joint.
Transformi...
... arthritis and the symptoms had lasted less
than 2 years.
At the first visit the rheumatologist answered a questionnaire
inquiring about the initial symptoms as reported by the patient
(type of ... promptly treated
with either methotrexate or salazopyrine (early treatment).
The rheumatologists that treated the patients were not aware
of the anti-CCP status of their patients because a...
... to worry about criticism. It is
important to emphasise that the MET service is ‘hospital
policy’ and that no hospital staff should be reprimanded for
calling the MET. Similarly, it is vital to ... improvement in the care of control
patients, with doctors and nurses imitating the intervention
being studied. It is also unethical to randomly assign acutely
ill patients, as it w...
... low.
Introduction
Rheumatoid arthritis (RA) is a chronic, autoimmune, inflamma-
tory disorder of unknown aetiology that is characterized by
symmetric synovitis and the propensity to cause joint destruc-
tion, ... Kleinheksel SM, Cathey MA: The mortality of
rheumatoid arthritis. Arthritis Rheum 1994, 37:481-494.
5. Emery P: Early rheumatoid arthritis: therapeutic strategies....
... Furthermore,
and with respect to previously expressed circumspection [10],
it is diligent to note that while proteolysis of SLRPs in articular
cartilage may yield tenable markers of arthritis ... shown to degrade
biglycan and fibromodulin (and to a lesser extent decorin and
lumican) in cartilage extracts; however, it is important to
appreciate that the proteolytic suscepti...
... follow-up visits and by stand-
ardized telephone interviews. Statistical analysis was done by
χ
2
test and linear multiple discriminant analysis for categorial
data and by t- tests for quantitative ... Germany
2
Department of Dermatology and Venereology, University of Rostock, Augustenstr, 18055 Rostock, Germany
3
Department of Pediatrics, Section of Pediatric Rheumatology and...
... differ between polyarthritis and oligoarthritis
patients (P > 0.46).
MBL association with disease parameters
Polyarthritis group
In the 67 patients with polyarthritis, patients in the low MBL2
genotype ... NS
Cumulative affected joints 3 (2 to 6) 4 (2 to 6) 2 (2 to 4) NS NS
Actively involved joints 0 (0 to 1) 0 (0 to 1) 0 (0 to 0) NS NS
Affected joints 1 (0 to 3) 1 (0 to 2)...
... qualitatively fewer Th2
Kong et al, Chitosan Interferon-c Nanogene Therapy for Lung Disease 99
be partially inactivated by CIN treatment, and their
capacity to activate T cells may consequently ... lungs determined by
TUNEL assay and measured by flow
cytometry. The data are based on
cytometry of a minimum of 15,000
cells and were substantiated by a
repeat experiment.
100 Aller...
... their
specific target substrates and limit the extent of proteolysis to
discrete pericellular regions [6]. These mechanisms are impor-
tant for regulating proteolytic activity. In osteoarthritis (OA), ... biology.
The combination of the cytokines IL-1 and oncostatin M
(OSM) added to cartilage explant cultures synergistically
induces the synthesis and activation of proMMPs, leading...
... consequence of impaired Th2
differentiation [12]. The nature of a T cell response, namely a
Th1 or Th2 response, is modulated by the strength of the
MHC–TCR contact, the nature of the co-stimulatory signals,
and ... proinflammatory cytokine tumor necrosis factor (TNF) more
than 10 years ago, huge efforts have been made to develop
inhibitors of p38 MAPK with the intent to...