... EAE lesions [3]. The latter focused on
the remyelination capacity of the CNS after an EAE attack.
Consequently, we postulate that glial elements along the
central canal and subpial regions are ... paralysis,
and finally, spontaneous recovery. These steps are matched
by an inflammatory response in the CNS, which is cha-
racterized by the infiltration of T cells and macr...
... Though the etiology is unknown[2], ONB
appears to arise from the olfactory membrane of the
sinonasal tract and prefere ntially involves the anatomic
distribution of the epithelium overlying the ... analysis. MEP, TLM, MM, and AKS wrote the manuscript. All authors
reviewed the statistical analysis results, contributed to the interpretation of
the results and...
... affect the
association of the substrate with the enzyme in any
one of several ways, e.g. through solvation effects on
substrates or enzyme active sites and through their
effects on the thermodynamic ... understanding the
effect of osmolytes on protein stability, folding and the
activity of proteins and enzymes, the relationship
between protein stabilization...
... formation of hydrogen bonds between
the nitrogen atoms of the ligands and the backbone
oxygen of Pro325. Although we did not directly com-
pare the molecular interaction energies of NMTIQ and
MPTP ... center of the catalytic site, the
latter prompting oxidation of the iron and consequent
hTH inactivation. TH inhibition by endogenous TIQs
depends critically o...
... any hydrogen bond with the protein
atoms. The former propionate displays the conserved
conformation in the structures of the Phe35fiTyr mutant
and of the wild-type protein as well as other mutants.
However, ... chain
conformation of this residue. The shift of the Ca atom of
Tyr35 of the Phe35fiTyr mutant from that of Phe35 of the
wild-type cyt b
5
is 0.21 A...
... of three copies of the O2S domain at the 5¢ end
of the CYC1 mini-promoter region. Following transfor-
mation of the URA-marked plasmid pLGD-265 UP1
containing the O2S domain and the TRP-marked ... transcription [4,5]. Rogers and Rogers
[4] found that both GARE and O2S functioned only when
positioned in one orientation with respect to each other and
with respect to...
... phospholipase A2 is in the nucleus of sub-
confluent endothelial cells but confined to the cytoplasm
of confluent endothelial cells and redistributes to the
nuclear envelope and cell junctions upon histamine ... cell. The
subcellular locations of these proteins also vary, with
some being present in the ER, others in the nuclear
membrane and some present at both these loca...
... suggest that the stabilization
of CD38 homodimers by crosslinkers depends strongly
on the conformation and orientation between the CD38
monomers.
It has been reported that NP-40 and Triton X-100
stabilize ... values of
each of the clones). The relative enzyme activity of each of the mutants is given in parentheses. It was determined by setting the V
max
adjusted...
... representing the beat locations. By further analysis
of the synchrony of the subband beats and the periodicity and regularity of the optimal beat, various possible cardiac events (in-
cluding fibrillation, ... signal, the narrowband (com-
plex) subbands are merged to obtain wideband-subband sig-
nals to be used for wideband event detection. The results of
the wide...