Different roles of functional residues in the hydrophobic binding site of two sweet orange tau pps
Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... examined the role of residues in the C-terminal extensions of other sHsps,notably aA- and aB-crystallin, the flexible regions of these proteins are unique and distinct from that of Hsp25. The ... residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity Amie M. Morris1, Teresa M. Treweek2, J. A. Aquilina1, John A. Carver3 and ... to the target protein, leading to a decrease in target protein binding [26]. In summary, the three negatively charged glutamic acid residues in the C-terminal extension of Hsp25(E190, E199 and...
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Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues in the sameenzyme.To obtain an insight into ... circulans, whereas it may be mutated toasparagine without loss of activity in other family 18 chitinases [28,30]. Preliminary results of a comparativestudy of available structures of family 18 chitinases ... mutation toglutamate or alanine that was observed in this study and previous studies on other family 18 chitinases [20,26,28–30]. Mutation of this residue to aspartate in other family 18 chitinases...
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Báo cáo khoa học: Leishmania donovani methionine adenosyltransferase Role of cysteine residues in the recombinant enzyme pptx
... [16].Ó FEBS 2003 Cysteine residues in leishmanial MAT (Eur. J. Biochem. 270)31 Leishmania donovani methionine adenosyltransferase Role of cysteine residues in the recombinant enzyme Yolanda Pe´rez-Pertejo1, ... domain of eachsubunit, in the interface between the two dimers compri-sing the tetrameric structure [29]. This domain containsfive cysteine residues, two of them (Cys35 and Cys61)forming a ... min. The role of the seven cysteine residues in L. donovani MAT was studied using the site-directed mutagenesisapproach, in which seven single mutants were produced,each lacking one of the sulfhydryl...
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Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
... of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.40 Laemmli UK (1970) Cleavage of structural proteinsduring the assembly of head of ... al. Functional role of the GST H -site residues FEBS Journal 277 (2010) 255262 ê 2009 The Authors Journal compilation ê 2009 FEBS 257 Different roles of functional residues in the hydrophobic binding ... product reveals two completely different binding modes for the intermediate and the product,suggesting that a specific motion is associated with the collapse of the intermediate into the product[34]....
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Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf
... 2010)doi:10.1111/j.1742-4658.2010.07685.x The hyperthermostable chitinase from the hyperthermophilic archaeon Pyrococcus furiosus has a unique multidomain structure containing two chi-tin-binding domains and two catalytic domains, and ... analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site Hiroaki Tsuji1, Shigenori Nishimura1, Takashi Inui1, Yuji Kado2, ... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B). The structures of boundsugars and the side-chains of three acidic residues in the conserved DXDXE...
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Báo cáo khoa học: Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis doc
... domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis Yingying Le 1, 2, Richard D. Ye3, Wanghua Gong4, Jianxiang Li 1 , Pablo Iribarren 1 and Ji Ming Wang 1 1 Laboratory ... G-protein-coupled receptor formyl peptide receptor-like 1. J Immunol 16 6, 14 48 14 51. 12 Quehenberger O, Prossnitz ER, Cavanagh SL, CochraneCG & Ye RD (19 93) Multiple domains of the N -formyl peptide ... substituting the segments in FPR with following corresponding parts in FPRL1: the N-terminus and N-terminal half of the first TM (A: chimera C), the C-terminal half of the first TM through the second...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
... important catalytic residues, indicating a role in binding the nucleotideinto the active site [15,16]. The crystal structure of CNS from Neisseria meningitidis crystallized in the presence of ... stereo-view of the residues of interest (blue) in the active site of the CNS from Neisseria meningitidis containing CDP(yellow) (PDB 1EYR) [12] superimposed with their equivalent residues (green) of the ... release. The increased mechanistic understanding gained from this study should allow incremental advances in the design and production of inhibitors and mimetics of CNS and other enzymes in the pathways...
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Báo cáo khoa học: Characterization of mutations in crucial residues around the Qo binding site of the cytochrome bc1 complex from Paracoccus denitrificans pdf
... despite the close prox-imity of the tyrosines to the Qo binding site. Most of the mutants studied here alter the spectral features of the quinone, indicating a variation of the hydrogen-bonding ... bc1complexes from other organisms. The mutated residues are highlighted in Fig. 1.Results Site- directed mutations in the Qo binding site Mutations in conserved positions of cytochrome b at the Qo site ... excess of stigmatellin.Upon binding of stigmatellin, shifts reflecting the changes within the binding site and the immediate envi-ronment are expected, together with signals for the inhibitor...
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Báo cáo hóa học: " Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function" docx
... of the individual cysteine residues in the extracellular domain in protein expression and cell fusion of the HRSV F protein and represents the first analysis of the contribution of the cysteine ... extracellular domain of the F protein of human parainfluenza virus 3 (hPIV3) has been solved [37]. The mature F protein of human respiratory syncytial virus (HRSV) contains fifteen cysteine residues ... bonds in Sendai virus [39], and based upon the positional conservation of the cysteine 69 residue in the HRSV F proteins with that of Sendai virus F protein and the F proteins from other of the Paramyxoviridae,...
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Different roles of functional residues in the hydrophobic binding site of two sweet orange tau pps
... of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.40 Laemmli UK (1970) Cleavage of structural proteinsduring the assembly of head of ... product reveals two completely different binding modes for the intermediate and the product,suggesting that a specific motion is associated with the collapse of the intermediate into the product[34]. ... nonoverlapping regions are, instead, localized in the H -site of the enzymes (Fig. 2B). These findings are in agreement with the different values of apparent Kmfor GSH observed between GSTU1 (REI) and the...
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Báo cáo lâm nghiệp: "Red deer density in the air-polluted area of forest ecosystems in the Krušné hory" pdf
... in the research area, mean values of the estimate of the red deer population density were deter-mined in the Jelení hora hunting district in 2007 and 2008 using the FSC method, viz 24 ± 23 individuals·km–2 ... (2): 59–63 59JOURNAL OF FOREST SCIENCE, 57, 2011 (2): 59–63Red deer density in the air-polluted area of forest ecosystems in the Krušné hory Mts.– Klášterec nad Ohří Forest DistrictZ. V, ... EDepartment of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Mendel University in Brno, Brno, Czech RepublicABSTRACT: The density of red deer in the area of forest...
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Báo cáo y học: "The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin" ppsx
... the numbers of arginine residues in the CDRs of these antibodies can lead to significant alterations in bind-ing to DNA. Arginines in VH CDR3 often play a particularlyimportant role in binding ... CDR3 of UK4VL hinders DNA binding sterically. A similar effectmay be occurring with regards to the binding of UK4VL to CL. The effect of point mutations of specific arginine residues in CDR3 ... arginine residues in IS4VHAs reported previously, the presence of the heavy chain of IS4 plays a dominant role in binding to CL [29]. IS4VHbinds CL in combination with six of the 10 light chainstested...
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Báo cáo y học: " Fluorodeoxyglucose-positron emission tomography/computed tomography in the staging and evaluation of treatment response in a patient with Castleman''''s disease: a case report" pps
... tomography/ computed tomography in the staging and evaluation of treatment response in a patient with Castleman's disease: a case reportEttore Pelosi*1, Andrea Skanjeti†2, Angelina ... in a patient with a mediastinal mass. Then, otherauthors reported new cases of the disease with differentlocalisations, including abdominal and superficial lymphnodes. The aetiology and pathogenesis ... drafting the manuscript. AC was involved in reviewing the literature and proofreading the manuscript. VA approved the finalmanuscript.ConsentWritten informed consent was obtained from the patient for...
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Báo cáo y học: "Large-scale discovery and validation of functional elements in the human genome" ppt
... goal of identifying all the functional elements in the human genome. The functional elements discussed at the meeting included protein-coding genes, reg-ulatory elements, RNA genes and DNA sequences ... [http://www.genome.gov/10005107]. The consortium, organized and funded by the National Human Genome Research Insti-tute, is initially focusing on designated regions comprisingapproximately 1% of the human genome, and it ... identification and the largenumbers of new candidate elements emerging from thesestudies. Snyder described a complete tiling of the non-repetitive human genome, with 134 arrays containing 52million...
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