...
TARGETING NEW
PATHWAYS AND CELL
DEATH IN BREAST CANCER
Edited by Rebecca L. Aft
Targeted Apoptosis in Breast Cancer Immunotherapy
27
clinical breast adenocarcinomas (Vinothini ... Suitable Candidate
for Breast Cancer Chemoprevention 157
Hsin-Ling Yang, K.J. Senthil Kumar and You-Cheng Hseu
Targeting New Pathways and Cell Death i...
... Suitable Candidate
for Breast Cancer Chemoprevention 157
Hsin-Ling Yang, K.J. Senthil Kumar and You-Cheng Hseu
Targeting New Pathways and Cell Death in Breast Cancer
36
other potent cytotoxic ... 1471-4892
Targeting New Pathways and Cell Death in Breast Cancer
38
between proliferation and a hypoxia metagene in aromatase inhibitor tre...
... human and murine cancer cells, it is
more damaging to human glioma brain cancer cells than to
HL-60 leukemia cells (data not shown); b) Ruta induces cell
division in normal human PBLs when grown in ... the arrest of cells in the G2/M phase,
induction of endomitosis and fragmentation of DNA, leading
to cell death; h) FACS analysis indicates that Ruta induces
cell death...
... cancer cell lines
Six NSCLC cell lines consisting of three adenocarci-
noma cell lines (A549, H522 and H358), two large carci-
noma cell lines (H460, H661), and one squamous cell
carcinoma cell line ... participated in acquiring clinical and laboratory data, data analysis and
interpretation, and drafted the manuscript. PP and LG participated in
acquiring clinical...
... these pathways play in repressing BIM and in
promoting aberrant cell survival in tumours that
harbour mutations in oncogenes which control these
pathways and (b) the role of BIM in tumour cell death
arising ... imatinib therapy have point
mutations in the BCR–ABL kinase domain, including
the T315I gatekeeper mutation that impairs imatinib
binding [58,59]. Accordingly...
... polyamine levels
in the cell. Careful regulation of the transport of polyamines
in and out of the cell also participates in keeping the
polyamine pools a t an a ppropriate level f or the ongoing
cellular ... caspase-dependent cell death in cultured human breast cancer
cells induced by the polyamine analogue
N
1
,
N
11
-diethylnorspermine
Cecilia Hegardt
1
, Oskar T. Johan...
... TNF-related apoptosis-inducing
ligand [3]. Although caspases play a crucial role in cell
death, increasing evidence suggests that cells can turn
on caspase-independent modes of cell death under a
variety ... AK, Ajay AK, Singh S & Bhat MK (2008)
Cell cycle regulatory protein 5 (Cdk5) is a novel down-
stream target of ERK1 ⁄ 2 in carboplatin induced death
of breast cancer...
... adenine nucleotide translocase-2 by vector-based
siRNA in human breast cancer cells induces apoptosis
and inhibits tumor growth in vitro and in vivo. Breast
Cancer Res 10, R11.
22 Shabalina IG, ... depletion
induced no major changes in cell cycle and in mito-
chondria aspect and network, and suggest that ADF
cells possess alternative mechanisms for providing
mito...