... molecules integrins in gastric
epithelial cells. In the present stu dy, the role of PAR-2 on H. pylori-induced cell death was investigated by
determining cell viability, DNA fragmentation, and the ... none (the cells without treatment and cultured in
the absence of H. pylori).
+
P < 0.05 compared to the corresponding
none (the cells without treatment and culture...
... However, no insertions of
A were observed in the any of these non-coding
sequences, showing that the high frequency of A inser-
tions was predominantly confined to the region encoding
the non-essential ... removed and/ or the
M2 termination signal was altered by the introduction of
the Swa I site.
Table 1: Frequency of GFP fluorescence in Vero cells infected with...
... were obtainable from the very young chicks, limit-
ing the scope of their investigation. Another group of
chickens was hatched and reared indoors, and serum sam-
ples collected at 9 weeks of age.
Plaque ... concentrated in the fertile egg and that the quantity
of these antibodies declines rapidly in the newly hatched
chick [13]. Our PRNT results are totally consi...
... towards the lower face of the β-
propeller (Fig. 3). The absence of overlapping of the MA
and IN binding sites and the possible occurrence of ter-
nary complex involving EED, MA and IN raised the ... protein. Mapping of the HIV-1 MA and IN binding sites on the
3D-model of EED core predicted that EED-bound MA and IN ligands would be in close vi...
... family of serine proteinase inhibitors. Serpins inhibit
their target proteinases by an ester bond being formed
between the active site serine of the proteinase and the P
1
residue of the reactive ... of the
covalent bond, the proteinase is translocated to the
opposite pole of the serpin [6–8], the active site becoming
distorted, the catalytic machinery inactiva...
... the
C-terminal part of MUC5AC harboring the von Wille-
brand C domain and cysteine-knot domain [16]. In the
case of 166M1, a very faint band corresponding to the
C2-H fragment was detected, indicating ... MUC5AC and that their epitopes are located
in the C-terminal cysteine-rich part of this mucin.
Results and Discussion
The recombinant C-terminal cysteine-rich par...
... deoxyribozyme 10–23 includes
the interactions of divalent cations with both the pro-
R
P
and proS
P
oxygens of P5, and an interaction with
the oxygen ligand at C6 of the subsequent guanosine
nucleotide ... Mn
2+
,Zn
2+
,orCd
2+
,in
increasing order (the rescue effect). Analysis of these
types of interaction led to a better understanding of the
mechanistic aspe...
... the arrow on the left indicates the beginning of the associ-
ation phase; the beginning of the dissociation phase is marked by the arrow on the right.
Interaction site between GAPDH and CP12 S. ... (analyte). The NaCl
concentration was increased from 0.15 m (HBS buffer) to
0.65 m as indicated in the text. The analyte interacts with
the ligand (CP12) to give...
... structural
insight into the organization of the substrate binding cavity and highlight
residues implicated in substrate ⁄ inhibitor binding in the S1¢ site of the
enzyme. To complement and extend the ... the vicinity of substrate ⁄ inhib-
itor binding pockets. The experimental results, together with the molecular
modeling, suggest that the amino acid residues...
... lymphodepleted patients with
melanoma in combination with high dose IL-2 has been
shown to achieve clinical responses in the range of 50%.
However, minimal activity of IL-2 in the treatment of
other cancers ... large numbers of high avidity
tumor-reactive CD8
+
T cells in individual patients in time
and maintain their survival in vivo. The solution is ge...