... annualbasis in North Carolina estuaries and coastal waters.(Burkholder et al. 1995) A series of large fish kills began in mid-Atlantic USA estuaries and coastal waters in the early1990s. Regional ... Models Data Analy., 5, 53–76,1989.Lane, D .A. , Kramer, M.S., Hutchinson, T .A. , Jones, J.K., and Naranjo, C., The causality assessment of adversedrug reactions using a Bayesian approach, Pharmaceut. ... again. This same process can be appliedto judging any hypothesis against its negation (∼H), a single alternate (H A ), several alternate hypo-theses (e.g., H A1 , H A2 , H A3 ). Equation 36. 3...