... started to investigate various aspects of proton dynamics in
cancer cells with quite encouraging preliminary results. The intent of unifying investigators involved in this research
line led to ... various aspects of
proton dynamics in cancer cells, with quite encouraging
preliminary results. With the intent of unifying investiga-
tors involved in this line of research the Fi...
... several LOX inhibitors, including aesculetin (a
nonselective LOX inhibitor), MK886 (an inhibitor of the
5-LOX-activating protein), zileuton (a 5-LOX inhibitor),
baicalein (a 12/15-LOX inhibitor), ... National Cancer Institute. Using a reverse-phase pro-
tein microarray assay, we determined molecular changes
in 77 protein biomarkers in an oncrasin-sensitive lung
cancer cell line after trea...
... eluted
using a salt gradient (0–200 mm NaCl contained in 500 mL
buffer A). Following an initial purification using Q-Seph-
arose resin a second chromatography step using the same
resin was required ... of the flavin does not ‘signal’ a change in the
binding geometry. Shifts in substrate position following
reduction of a cofactor have been postulated in other
enzyme systems, including cy...
... ELIS-
POT, intra-cellular cytokine staining and major histocom-
patiblity multimer staining [45]. Understanding the
cryobiology principles that explain cellular function after
preservation is becoming ... Foster M, Martin B, Wang E, Smith K, Marin-
cola FM: Forecasting the cytokine storm following systemic
interleukin-2 administration. J Transl Med 2004, 2:17.
115. Rossi L, Martin B, Hortin G...
... reducing their number or inhibiting their effector
functions intuitively has the potential of increasing the
efficacy of anti-tumour immunity. While increasing pre-
clinical data support this hypothesis, ... unan-
swered issues in this emerging basic and clinical research
area in animal models and man toward delineating, e.g.,
the relative effects of T cells and depletion of Tregs. In t...
... for
biospecimens is resulting in the transformation of
biobanking from an immature 'cottage industry' con-
ducted by individuals, into a complex institutional activ-
ity [5,6]. Biobanking has expanded ... complications inherent in
imposing complex research collection protocols on the
routine workflow of distinct clinical organizations. These
issues also relate to the difficulty...
... surfaces (e.g.,
skin, lining of the intestine) against bacteria, and plays a
critical role in chronic intestinal inflammation [24,25].
The unchanged IL-17 and IL-23 levels in CFS noted in this
study ... evaluation tool in Clinical Med-
icine. Clin Chem 1993, 39:561-577.
23. Waldmann TA: The biology of interleukin-2 and interleukin-
15: implications for cancer therapy and vaccine desig...
... regulating the innate and adap-
tive immune systems. Cytokines are thus upregulated in
the brain in a variety of diseases, including stroke. In the
brain, cytokines are expressed not only in the ... area of research in translational medicine.
Cytokines and brain inflammation
Cytokines are a group of small glycoproteins that are pro-
duced in response to an antigen and were origina...
... Exp Med 1989, 170:827-845.
42. Kubin M, Kamoun M, Trinchieri G: Interleukin 12 synergizes with B7/CD28
interaction in inducing efficient proliferation and cytokine production of
human T cells. ... circulating APC populations.
Cytokine production in VK3-20-loaded PBMCs
In order to evaluate the impact of the VK3-20 protein
stimulation on the production of cytokines involved in
Table 1 C...