... linking the active site tyrosine residue of
topoisomerase I with the 3¢ terminus of DNA in topo-
isomerase I DNA complexes which accumulate during
treatment of cancer with camptothecin. In yeast, ... torsion-
al strain of DNA during replication, repair and transcrip-
tion processes by making single stranded breaks on DNA,
unwinding and religating the DNA ends...
... competitive
inhibitor against dihydroxyacetone phosphate and
NAD(P)H. However, NAD(P)
+
acted as a competitive
inhibitor against NAD(P)H and as a noncompetitive
inhibitor against dihydroxyacetone ... distinct features from
eubacteria and eukaryotes, including the unique stereo-
chemical backbones of phospholipids in their cellular
membrane. The core lipid of the phospholipids and...
... (rutin)
Quercetin-4¢-GlA
Kaempferol-3-Glc
Isorhamnetin-3-Glc
Flavanones Naringenin-7-GlcRha (naringin)
Hesperetin-7-GlcRha (hesperidin)
Dihydrochalcones Phloretin-7-Glc (phlorizin)
Secoiridoids Oleuropein
Anthocyanidins Cyanidin-3-Glc ... similarity and 83.6 % ami no-
acid similarity with gu inea pig C BG, and showed homol-
ogy w ith domains III and I V o f mammalian LPH (56 and
57% amino-a...
... consistent with titration of the
catalytic histidine, H438(440). The persistence of activity in
the presence of the protonated form of the catalytic histidine
is inconsistent with the generally ... catalytic
site (i. e. a catalytic triad of Ser-His-Glu, an oxyanion hole, a
p-cation-binding site, and an acyl-binding pocket) are the
same in AChE and BuChE (Fig. 1...
... cells is the same
size as the polypeptide identified in crude extracts of spinach
leaves by antibodies raised against the recombinant protein.
The size of this protein is very similar to t hat of ... for
Fru-2,6-P
2
ase activities in the liver isoform of t he mamma-
lian enzyme are conserved in the same relative positions
within the spinach leaf sequence (Fig. 1)....
... rod linker,
which resulted in the disintegration of the rod complexes.
The two bilins present in b-phycocyanin give a greater
contribution to the UV absorption than the s ingle bilin of the
other ... components, and the
individual biliproteins, either with or without attached
linkers, are obtained [6]. The relative stability of biliprotein-
linker complexes varies am...
... first obvious difference in their
catalytic properties to be identified. Kinetic data were
consistent with the inhibition due to binding of the second
substrate. We discuss the inhibition mechanism ... contribu-
tion of the aliphatic chain of fatty acids to their binding, as
compared with P450BM3. In other words, the interaction of
P450foxy with the carboxylate anion o...
... sensitivities found in our
study were higher in comparison to the study in
question but specificity is lower. This situation may be
related with the phase of the brucella infection.
In a study ... agglutination tests have an important
role in the diagnosis of brucellosis. Main antigenic
structure which is imported in the diagnosis of bru-
cellosis is the s...
... currently an associate professor in
Department of Biochemistry and Nutrition in Iran University of Medical Sciences. He is
interested in study of nutrition and trace elements in human blood.
Manuchehr ... Imamian obtained BSc in Chemistry from Payam-Nour University of IRAN in
1996 and MSc in Biochemistry from Iran University of Medical Sciences in 2001. His a...
... iron and lipids [14,56,57] may be
relevant in a variety of liver diseases. It is anticipated
that iron overload in hepatic cells in clinical situations
in vivo might cause changes in lipid metabolism
and ... accumulation and
(c) increased the prooxidant state and the level of
oxidatively modified proteins. These results are in
accordance with previous in vitro and in vi...