... exclusively, mostsplicing enhancers tend to bind SR proteins, a familyof proteins containing one or two RNA-bindingdomains and a signature RS domain rich in Arg ⁄ Serdipeptides, and splicing silencers ... ISSs. In thisstudy, we show that PRE-ISS effectively inhibitsexon 7 inclusion in the SMN1 splicing context, indicat-ing that PRE-ISS activates an inhibitory mechanismoutcompeting the exon 7 inclusion ... elements in the neighboring introns of SMNexon 7 repress exon inclusion in its SMN2, but notSMN1, splicing context [23,27,28], suggesting that theexon 7 inclusion mechanism in the SMN1 splicing...