Báo cáo khoa học: Protein interactions in the sumoylation cascade – lessons from X-ray structures pdf

Báo cáo khoa học: Protein interactions in the sumoylation cascade – lessons from X-ray structures pdf

Báo cáo khoa học: Protein interactions in the sumoylation cascade – lessons from X-ray structures pdf

... RanGAP1. Their comparison provides insight into the protein interactions underlying sumoylation, and suggests how SUMO proteins may be translocated between enzymes during the various steps of the protein ... final product of the sumoylation cascade [SUMO(C)]. The modeled and resolved structures discussed above allow rationalization of the protein interactions occur...
Ngày tải lên : 30/03/2014, 04:20
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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot

Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot

... complexed with the minor groove binding drug netrop- sin. Biochemistry 36, 479 2–4 799. 13 Patel DJ (1982) Antibiotic–DNA interactions – inter- molecular nuclear Overhauser effects in the netropsin- d(CGCGAATTCGCG) ... cataloging the structure to class I. As the bulky NH 2 group on guanine was believed to prevent binding of the drug in the minor groove, the detailed...
Ngày tải lên : 16/03/2014, 22:20
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Báo cáo khoa học: Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum pdf

Báo cáo khoa học: Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum pdf

... are in keeping with other LDHs. With regard to the nature of the rate-determining steps, conformational rearrangement is the predomin- ant kinetic barrier in the single-turnover reaction, i.e. in ... determine the pKa of the ionizable group at the active site. The K M for pyruvate was determined from rates measured for 8–1 0 dif- ferent pyruvate concentrations in 2...
Ngày tải lên : 23/03/2014, 09:20
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Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

... probably be able to inhibit protein protein interactions in which Keywords activator protein- 1; coiled coils; electrostatic interactions; protein design; protein folding Correspondence J. M. Mason, ... permitting a rigid interpretation in distinguish- ing interacting from noninteracting proteins. One Fig. 1. Schematics of library designs. The helical wheel diagram looks dow...
Ngày tải lên : 18/02/2014, 13:20
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt

Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt

... cannot be predicted from the amino acid sequence, we were very interested in analyzing whether ILT2 nitration affected the Tyr residues in the hydro- phobic interdomain that binds HLA-G. To address this ... loss [23], protein nitration can also elicit increased biological activity, such as in cathep- sin D [24], or in the glucocorticoid receptor, where nitration leads to a...
Ngày tải lên : 07/03/2014, 02:20
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Báo cáo khoa học: Protein transport in organelles: The Toc complex way of preprotein import pdf

Báo cáo khoa học: Protein transport in organelles: The Toc complex way of preprotein import pdf

... contains three TPR motifs forming the docking site for Hsp90-bound preproteins. AtToc12 (12) exposes a J-domain (J) into the intermembrane space and has a role in anchoring Hsp70, thereby assisting ... translocation of the photosyn- thetic preproteins (down-regulated in the mutants) is unclear. However, many proteins that are not involved in photosynthesis (termed ‘housekeeping...
Ngày tải lên : 07/03/2014, 03:20
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Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx

Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx

... Transmembrane domains are depicted as columns. Regions involved in membrane binding are coloured in red, motifs involved in protein protein interaction are blue and the dehydrogenase domains of Tic32 ... hypothesized that the protein exists in a closed conformation, in which the TPR domain shields the Hip/Hop-domain from the chaperone. Surprisingly, the TPR motifs...
Ngày tải lên : 07/03/2014, 03:20
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Báo cáo khoa học: Protein transport in organelles: Protein transport into and across the thylakoid membrane pptx

Báo cáo khoa học: Protein transport in organelles: Protein transport into and across the thylakoid membrane pptx

... for the interaction of the preprotein with the receptor. The 16 ⁄ 23 chimera is retarded dur- ing translocation; early in the process, the protein assumes a structure within the membrane in which ... an N-terminal domain called the GTPase- containing domain (G-domain). CpSRP54 also has a second domain designated the methionine-rich domain (M-domain) [48]. Within cpSRP4...
Ngày tải lên : 07/03/2014, 03:20
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

... mutants (the IEP of the Ll.ltrB intron of Lactococcus lactis) have suggested that the N-terminus of the RT domain is required for protein interactions with the high-affinity binding site in subdomain ... splicing of the intron RNA into the insertion site in the DNA are shown at the top. Solid lines indicate DNA and dashed lines correspond to intron RNA. M. D. Molina-Sa...
Ngày tải lên : 15/03/2014, 09:20
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Báo cáo khoa học: Protein transport in chloroplasts ) targeting to the intermembrane space pptx

Báo cáo khoa học: Protein transport in chloroplasts ) targeting to the intermembrane space pptx

... (Fig. 1A, lanes 4–6 ). The import of QORH into the inner enve- lope of chloroplasts was shown to depend on targeting information present in the C-terminus of the pre- protein [11]. Therefore, we ... binding and hydrolysis [ 4–7 ]. Toc34 GDP interacts with the second G -protein in the Toc complex, Toc159, and simultaneously transfers the preprotein to Toc159. Toc159 ac...
Ngày tải lên : 23/03/2014, 07:20
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