... 4971
MINIREVIEW
Active-site-specific chaperone therapy for Fabry disease
Yin and Yang of enzyme inhibitors
Jian-Qiang Fan
1
and Satoshi Ishii
2
1 Department of Human Genetics, Mount Sinai School of Medicine, ... 000 for the classic form.
The incidence of the variant form of Fabry disease
was found to be higher. Screening of various ethnic
groups reveal...
... cells are a useful
model for studying mechanisms of regulation and func-
tions of TSC22D isoforms in mammalian kidney cells.
The lack of previous evidence for expression of sev-
eral TSC22D transcripts ... Master Mix
(Applied Biosystems) and 30 pmol of each primer. PCR
conditions were 50 °C for 2 min and 95 °C for 10 min, fol-
lowed by 40 cycles of 95 °C for 15 s...
... were analyzed by
PCR (35 cycles of 94 °C for 15 s, 60 °C for 15 s, and 72 °C
for 30 s), using a set of specific primers for the human hsp70
gene between )272 and )13 (forward, 5¢-CCA TGG AGA
CCA ACA ... spliced form of Hsp105a that is expressed specifically during mild
heat shock. In a report, it was shown that Hsp105a and Hsp105b localize
to the cytoplasm and of nucleus...
... onger i soform CfAFP-501 using
the main chain of residues Thr23fiAsn90 in i soform 337 and residues
Thr54fiMet121 in CfAFP-501. (B) Overlap of isoforms 337 and 501
using the main chain of r esidues ... comparison of isoform
sequences can d emonstrate which residues are important for
a protein’s function and structure. A list of known i soforms
may be found in Doucet et al. [ 5...
... in the form
of sets of semantic pairs. A semantic pair (SP)
is a qualified piece of information that the dia-
50
logue system is able to understand. For exam-
ple, a system could understand semantic ... status of the system, and then focus
on how this system is used to elicit useful
data for supporting hypotheses about mul-
timodal interaction in the domain of meet-
ing retriev...
... system is for sentences rec-
ognized by OCR, and it uses character transition
probabilities and POS (part of speech) tag n-gram.
However it needs a word dictionary and takes long
time for searching ... sentence
T
and candidates consist of
Eumjeol and the blank character .
C
i
s
i
b
nn
bsbsbsbsT
332211
=
.
332211 nn
bsbsbsbsC
=
(2)
(n is the number of Eumjeols)...
... word and repre-
sents a specific source word.
Category if and only if
1
2 and
2 and
3 and
3 and
6 and
7 and
for the word pair , we use the following
categories of features:
1. ( )
2. ( ) and
3. ... features:
1. ( )
2. ( ) and
3. ( ) and
4. ( ) and
5. ( ) and
6. ( ) and
7. ( ) and
8. ( ) and
9. ( ) and
Category 1 features depend only on the source
word an...
... digestive process of the insect.
Two forms of pancreatic-like carboxypeptidases, CPA
and CPB, are involved in the degradation of dietary
proteins. The two isoforms of CPA, A1 and A2, differ in
specificity ... extracts for the first and the last of the tested inhibitors
[3]. Thus, the N-terminal sequence of the recombinant
enzyme, its ability to be activated by trypsin an...
... record
additional information, including the source of
each sentence pairs, metadata, and the information
on phrase and word level alignment. With that ad-
ditional information, TotalRecall ... look for instances of specific words or ex-
pressions. For this purpose, the system opens up
two text boxes for the user to enter queries in any
one of the languages involved or bo...
...
AI~ e
2.
For each tree of the
fonowing
form include
Aa\Ba/C ¢ E f(e) and A¢\Ba/C ¢ E f(e)
A
NA
BOA C
OA
I I
A
NA
3. For each tree of the following form
Aa/B¢/C e.E f(e) and Ae/Be/C ...
include
4. For each tree of the following form include
A°\AI E
f(e), A*\AI E f(e) and A, E f(a,)
ANA
al A
NA
5. For each tree of the following form include
A °/Ai E...