... affect the
association of the substrate with the enzyme in any
one of several ways, e.g. through solvation effects on
substrates or enzyme active sites and through their
effects on the thermodynamic ... (a) the
main driving force for the folding is the unfavourable
interaction between the osmolyte and the peptide back-
bone, and (b) the total contribution of...
... while the other one extends into the solvent
and does not form any hydrogen bond with the protein
atoms. The former propionate displays the conserved
conformation in the structures of the Phe35fiTyr ... toward the heme.
The mutation from the nonpolar residue Phe35 to the polar
residue Tyr35 makes slight changes in the side chain
conformation of this residue. Th...
... stabilize the homodimers (data
not shown). These results suggest that the stabilization
of CD38 homodimers by crosslinkers depends strongly
on the conformation and orientation between the CD38
monomers.
It ... expression of CD38 on the plasma membrane
and the half-lives of these CD38 mutant proteins on the
plasma membrane were significantly reduced. Together,
thes...
... For other controls, pri-
mary or secondary antibodies were omitted.
Acknowledgements
The authors are obliged to Professor Rolf Howlett for
the preparation and donation of wound specimens
and Drs ... upstream of the transcrip-
tion initiation site, untranslated intron 1 and sequences
upstream of exon 1, were used to evaluate activities of
deletion constructs after transient...
... represents
the node, “X” represents the constitute label, the
headword or POS of the headword of the node.
In the following, the units of PIQ are bits.
Conclusion
Among the feature types in the same ... possibility to modify the headword)
the exact headword information 3.7333
(Y= the headword of the current constitute)
Conclusion
The predictive informat...
...
Reduplication is the verbal reduplication
morpheme. Of interest in this example are
regressive Vowel Harmony 4, and, of course,
reduplication. The input consists of the stream
of segments and a ...
cliticization.
Also exemplary of the division of duty
between the morphophonological parser and
the syntactic parser is the dual status of
subcategorization...
... in concert, their
effect is much greater than the sum of the individual
parts. Indeed, the effect of the double-alanine substitu-
tion of basic residues within the Jun-Fos heterodimer
on the ... substitu-
tion of all other residues reduces the binding of the
Jun-Jun homodimer to DNA by more than one order
of magnitude, even though alanine substitution of
th...
... indicate
that a functional deletion of Synoviolin causes a change
in the intracellular trafficking of NCT.
Effect of Synoviolin on the production of Ab
NCT is one of the essential cofactors of the c-secretase
complex. ... most
likely that the accumulation of NCT in synoviolin-null
cells is a result of the suppression of the degradation
of NCT. To further i...
... binding to a con-
sensus element within the long control region of the
viral genome, and also functions together with the E1
protein in viral DNA replication [16].
The E2 protein consists of the N-terminal ... inter-
actions of SR proteins [1–5]. Reversible phosphoryla-
tion of SR proteins is important for assembly and
function of the spliceosome and for proper reg...
... ATP-dependence of proteolysis of r
32
by HflB. (Upper)
Band corresponding to r
32
on 11% SDS ⁄ PAGE, in the presence or
absence of 5 m
M ATP. Numbers on the top of each lane indicate
the time of digestion ... this
mode of antiproteolytic action of CIII a general mode
of CIII activity, or does it apply only for CII? We
examined the mode of the inhibitory action...