Báo cáo khoa học: Interﬂavin electron transfer in human cyto

Báo cáo khoa học: Interﬂavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding docx

... human cytochrome P450 reductase (Eur. J. Biochem. 270) 2621 Interﬂavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding Relaxation kinetic studies with coenzyme ... bound to the enzyme predominantly through interactions involving its adenine end, whose binding site is contained within the FAD -binding domain of the...

Ngày tải lên : 23/03/2014, 17:22

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Báo cáo khoa học: Inter-ﬂavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx

... kinetics of cytochrome P450 reductase: internal electron transfer is limited by confor- mational change and regulated by coenzyme binding. Biochemistry 41, 4626–4637. 35 Marcus RA & Sutin ... in the mechanism of electron transfer in this complex ﬂavoprotein. Abbreviations CPR, cytochrome P450 reductase; di-sq, di-semiquinone; ET, electron transfer; hq, h...

Ngày tải lên : 07/03/2014, 06:20

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Báo cáo khoa học: Kinetics of electron transfer from NADH to the Escherichia coli nitric oxide reductase ﬂavorubredoxin pdf

... oleovorans rubredoxin reductase- rubredoxin electron transfer complex. Biochemistry 37, 15513–15522. 23 Ghisla S & Edmondson DA (2001) Flavin Coenzymes. In Encyclopedia of Life Sciences. Nature Publishing Group. ... NO, FlRd has to be reduced by NADH via the FAD -binding protein ﬂavorubredoxin reductase, thus the kinetics of electron transfer along this pathway was inves...

Ngày tải lên : 16/03/2014, 11:20

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

... ⁄ LEDGF-interacting domain linked to DNA -binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the FYRC domain and the ... denominator in all different MLL rearrangements is disruption of the MLL protein in a region that prevents any subsequent protein–protein interaction between the resulting MLL fusion prote...

Ngày tải lên : 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx

... cyclin dependent kinase 4 is controlled by multiple mechanisms, including phosphorylation of tyrosine 17. This site is equivalent to tyrosine 15 of cyclin dependent kinase 1, which undergoes inhibitory ... that this phosphorylation is independent of p27 KIP1 . The ﬁnding that Y17 phosphorylation is mediated by Src family kinases is completely novel and it is interesting to n...

Ngày tải lên : 18/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf

... by unwinding [38] and are potential sites for aggregation of S ⁄ MAR -binding proteins. In this view, the direct association between DNA-PK and S ⁄ MAR-DNA or -binding proteins is a considerable point. ... analysis of the temporo-spatial distribution of DNA repair factors in situ in living cells has been providing us with striking information. For instance, even following exposur...

Ngày tải lên : 19/02/2014, 06:20

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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx

... of this signaling pathway also enhances metabolism, resulting in an increase in glucose uptake and an up-regulation of glycolysis [37,38]. In addition, PI3K signaling has been shown to be involved ... nonfat milk in NaCl ⁄ Tris containing 0.2% Nonidet P40, incubated with primary antibodies overnight at 4 °C and washed in NaCl ⁄ Tris–Tween (0.1% Tween-20). Immu- noblotting was detect...

Ngày tải lên : 07/03/2014, 00:20

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Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx

... Site-directed mutational analysis for the ATP binding of DnaA protein. Functions of two conserved amino acids (Lys-178 and Asp-235) located in the ATP -binding domain of DnaA protein in vitro and in vivo. J Biol ... adenosine 5¢-(b,c-imido)triphosphate, indicating that in order to inhibit iron regulatory protein-1 binding activity, ATP must be hydrolyzed. Indeed, recombinant ir...

Ngày tải lên : 07/03/2014, 09:20

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Báo cáo khoa học: Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopy docx

... dynamics. Biochemistry 35, 7692–7704. 19 Steinhoff HJ (2004) Inter- and intra-molecular distances determined by EPR spectroscopy and site-directed spin labeling reveal protein-protein and protein-oligonucleo- tide ... spin-labeling experiments could reveal where these interactions originate from, either by mutation of the possibly interacting residues or by using double site-directed sp...

Ngày tải lên : 16/03/2014, 01:20

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Báo cáo khoa học: Internalization of cystatin C in human cell lines docx

... as shown by ELISA. A plateau noted for the increase in cystatin C at longer incuba- tion times is likely due to increased competition with cystatin C -binding proteins (i.e. target cysteine proteases) ... proteases is balanced by tight -binding inhibitors, the cystatins [4]. The cystatin protein family comprises three major groups of inhibitors: type 1 cystatins, also called s...

Ngày tải lên : 16/03/2014, 06:20

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