Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

... MINIREVIEW Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP -1) and its molecular partner HIPPI in the regulation of apoptosis and transcription Nitai P. ... chain B; ENTH, Epsin N-terminal homology; HD, Huntington’s disease; HIP -1, huntingtin-interacting protein 1; HIPPI, huntingtin-interacting protein 1 interactor; Htt...
Ngày tải lên : 23/03/2014, 07:20
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Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx

Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx

... displacement of water molecules and hence render the protein insoluble. This theory was consistent with the genetic gain -of- function seen with mutant proteins in HD, in the ataxin -1 protein in spinocerebellar ... fragment of huntingtin in a polyglutamine-dependent manner of close to four-fold over Q138 huntingtin 1 17 1. Thus, loss of structure in regions ad...
Ngày tải lên : 23/03/2014, 07:20
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Báo cáo khoa học: Huntington’s disease: degradation of mutant huntingtin by autophagy doc

Báo cáo khoa học: Huntington’s disease: degradation of mutant huntingtin by autophagy doc

... mutant huntingtin clearance and increased the levels of soluble and aggregated mutant huntingtin in HD cell models [11 ]. Furthermore, rapamycin treatment increased mutant huntingtin clearance and decreased the ... repeat (> 35 repeats) in the huntingtin gene, which is translated into an expanded polygluta- mine tract in the N-terminus of the huntingtin protein....
Ngày tải lên : 23/03/2014, 07:20
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Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models pot

Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models pot

... progress in molecular genetics has identified several genes causing PD, including a-synuclein, leucine-rich repeat kinase 2 (LRRK2), Parkin, DJ -1 and PTEN-induced kinase 1 (PINK1), many of them coding ... injection of epoxomicin and other prote- asomal inhibitors blocked MPP + - or rotenone-induced dopamine neuron death in rats and induced round a-synuclein IR inclusions i...
Ngày tải lên : 07/03/2014, 05:20
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Báo cáo khoa học: A new bright green-emitting fluorescent protein – engineered monomeric and dimeric forms pptx

Báo cáo khoa học: A new bright green-emitting fluorescent protein – engineered monomeric and dimeric forms pptx

... towards monomer. The corresponding amino acid residues in VFP are H1 21, N158, T160 and T176, allowing us to identify possible mutations in VFP as H121R, N158K and T160R. We focused on examining the N158K and T160R ... (B) Structure of two of the four subunits of the tetrameric DsRed consisting of the AC polar interface. The positions of the amino acid residu...
Ngày tải lên : 06/03/2014, 11:20
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Báo cáo khoa học: Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma ppt

Báo cáo khoa học: Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma ppt

... Calbin- din-D28k and calcium sensing receptor cooperate in MCF-7 human breast cancer cells. Int J Oncol 24, 11 11 11 19. 59 Volpert OV, Lawler J & Bouck NP (19 98) A human fibrosarcoma inhibits ... adaptation of RCC cells to the lack of calbindin protective function. The protection from apoptosis despite the lack of cal- bindin could be explained by the decrease in T...
Ngày tải lên : 07/03/2014, 05:20
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Báo cáo khoa học: "From Single to Multi-document Summarization: A Prototype System and its Evaluation" pptx

Báo cáo khoa học: "From Single to Multi-document Summarization: A Prototype System and its Evaluation" pptx

... (1) 37.52% (2) 17 .92% (2) 61. 01% (1) 41. 21% (1) 23.90% (2) 63.34% (1) 38. 21% (3) 21. 30% (2) 58.79% (1) 36.34% (2) 16 .44% (2) 51. 72% (1) 34. 31% (3) 10 .98% (3) Y 41. 51% 41. 58% (1) 17 .78% ... 54.78% 33. 81% 19 .86% 45.59% 27.80% 13 .27% 41. 89% 23.40% 9 .13 % 31. 30% 24.07% 5.05% R 41. 86% 27.63% 11 .19 % 48.63% 24.80% 12 .15 % 43.96% 31. 28%...
Ngày tải lên : 17/03/2014, 08:20
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Báo cáo khoa học: "Sequential Labeling with Latent Variables: An Exact Inference Algorithm and Its Efficient Approximation" ppt

Báo cáo khoa học: "Sequential Labeling with Latent Variables: An Exact Inference Algorithm and Its Efficient Approximation" ppt

... and inference time of the DPLVM-LDI model against the parameter n on the NP- chunking development dataset. (Right) Enlarge- ment of the beginning portion of the left figures. The curves echo the ... (y  )f EVAL (y|y  ). (13 ) The intuition behind our MBR reranking is the 778 Models Pre. Rec. F 1 Time LDI-A 91. 76 90.59 91. 17 42 s LDI-A + MBR 92.22 90.40 91. 30 61...
Ngày tải lên : 17/03/2014, 22:20
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Báo cáo khoa học: Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells pot

Báo cáo khoa học: Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells pot

... important in the process of OA-induced apoptosis [13 ], whereas another showed that OA induces apoptosis in the human breast carcinoma cell line MCF-7, which lacks expression of caspase-3 [14 ]. Furthermore, ... cells and examined the effects of gene knockout and treatment with caspase-3 inhibitors. Okadaic acid (OA) is a potent inhibitor of the serine⁄ threonine...
Ngày tải lên : 22/03/2014, 21:20
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Báo cáo khoa học: Helicobacter pylori single-stranded DNA binding protein – functional characterization and modulation of H. pylori DnaB helicase activity pptx

Báo cáo khoa học: Helicobacter pylori single-stranded DNA binding protein – functional characterization and modulation of H. pylori DnaB helicase activity pptx

... contain- ing bacterial lysate confirming the expression of HpSSB in H. pylori (Fig. 1C). There is a difference in the migration of the recombinant protein and the endogenous protein because the ... replication foci; single-stranded DNA binding protein Correspondence S. K. Dhar, Special Centre for Molecular Medicine, JNU, New Delhi 11 0067, India Fax: + 91 11 267...
Ngày tải lên : 30/03/2014, 02:20
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