Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... MINIREVIEW
Huntington’s disease: roles of huntingtin-interacting
protein 1 (HIP -1) and its molecular partner HIPPI in the
regulation of apoptosis and transcription
Nitai P. ... chain B; ENTH, Epsin N-terminal homology; HD, Huntington’s disease; HIP -1, huntingtin-interacting protein 1; HIPPI,
huntingtin-interacting protein 1 interactor; Htt...
... displacement of water molecules
and hence render the protein insoluble. This theory
was consistent with the genetic gain -of- function seen
with mutant proteins in HD, in the ataxin -1 protein in
spinocerebellar ... fragment of
huntingtin in a polyglutamine-dependent manner of
close to four-fold over Q138 huntingtin 1 17 1. Thus,
loss of structure in regions ad...
... mutant huntingtin clearance and increased the
levels of soluble and aggregated mutant huntingtin in
HD cell models [11 ]. Furthermore, rapamycin treatment
increased mutant huntingtin clearance and decreased
the ... repeat (> 35 repeats) in the huntingtin
gene, which is translated into an expanded polygluta-
mine tract in the N-terminus of the huntingtin protein....
... progress in molecular genetics has identified several
genes causing PD, including a-synuclein, leucine-rich repeat kinase 2
(LRRK2), Parkin, DJ -1 and PTEN-induced kinase 1 (PINK1), many of
them coding ... injection of epoxomicin and other prote-
asomal inhibitors blocked MPP
+
- or rotenone-induced
dopamine neuron death in rats and induced round
a-synuclein IR inclusions i...
... towards
monomer. The corresponding amino acid residues in
VFP are H1 21, N158, T160 and T176, allowing us to
identify possible mutations in VFP as H121R, N158K
and T160R. We focused on examining the N158K and
T160R ... (B)
Structure of two of the four subunits of the tetrameric DsRed
consisting of the AC polar interface. The positions of the amino
acid residu...
... Calbin-
din-D28k and calcium sensing receptor cooperate in
MCF-7 human breast cancer cells. Int J Oncol 24,
11 11 11 19.
59 Volpert OV, Lawler J & Bouck NP (19 98) A human
fibrosarcoma inhibits ... adaptation of
RCC cells to the lack of calbindin protective function.
The protection from apoptosis despite the lack of cal-
bindin could be explained by the decrease in T...
... and inference time of the DPLVM-LDI
model against the parameter n on the NP-
chunking development dataset. (Right) Enlarge-
ment of the beginning portion of the left figures.
The curves echo the ... (y
)f
EVAL
(y|y
). (13 )
The intuition behind our MBR reranking is the
778
Models Pre. Rec. F
1
Time
LDI-A 91. 76 90.59 91. 17 42 s
LDI-A + MBR 92.22 90.40 91. 30 61...
... important in the process of OA-induced
apoptosis [13 ], whereas another showed that OA
induces apoptosis in the human breast carcinoma cell
line MCF-7, which lacks expression of caspase-3 [14 ].
Furthermore, ... cells and examined the effects of gene knockout
and treatment with caspase-3 inhibitors. Okadaic acid (OA) is a potent
inhibitor of the serine⁄ threonine...
... contain-
ing bacterial lysate confirming the expression of
HpSSB in H. pylori (Fig. 1C). There is a difference in
the migration of the recombinant protein and the
endogenous protein because the ... replication foci; single-stranded
DNA binding protein
Correspondence
S. K. Dhar, Special Centre for Molecular
Medicine, JNU, New Delhi 11 0067, India
Fax: + 91 11 267...