Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... FEBS
MINIREVIEW
LRRK2 in Parkinson’s disease: in vivo models and
approaches for understanding pathogenic roles
Zhenyu Yue
Department of Neurology and Neuroscience, Mount Sinai School of Medicine, ... and LRRK2 homo-
logs in slime mold, nematode worms and fruit flies. It also discusses the
results obtained from available mouse models of LRRK2 that begin t...
Tài liệu Báo cáo khoa học: "Accumulation of Lexical Sets: Acquisition of Dictionary Resources and Production of New Lexical Sets" pdf
... source, human work in grammar writing
and machine work in parsing can be reduced
significantly.
(2) Obtaining the result immediately without
parsing. In some simple cases, using several
replacement ... we will examine several
common categories of production, point out
basic operations often used in them, and finally,
establish and implement a formalism for
specifying...
Báo cáo khoa học: "A Rose is a Roos is a Ruusu: Querying Translations for Web Image Search" pdf
... to coil and none to
the jumping sense. Simple modifications to query
do not always work. Searching for spring water
results in many images of bottles of spring water
and searching for spring jump ... Word + Random (SW+R): Querying with
three pairs of source word and a random transla-
tion. This is another natural way to extend the
baseline for the intended sense. (4) Random (R):...
Báo cáo khoa học: "USING AN ONLINE DICTIONARY TO FIND RHYMING WORDS AND PRONUNCIATIONS FOR UNKNOWN WORDS " doc
... techniques for segmenting and
matching word spellings, and for mapping spelling to
sound in known words. As in the case of rhyme, the
computer model will be an important tool for improving
our understanding ...
uridine
uriel
urim and thumm
urinal
urinalysis
urinary
urinate
urination
urine
urinogenital
urinometer
urinometric
detergency
surgeoncy
insurgency...
Báo cáo khoa học: "Phrase-based Statistical Language Generation using Graphical Models and Active Learning" potx
... riverside inform(area)
area inform(area) area inform
that inform inform EMPTY
serves inform(food) food inform
French inform(food(French)) French inform(food)
food inform(food) food inform
</s> ... Chinese restaurant near Cineworld in the centre of town
Charlie Chan Chinese restaurant Cineworld centre
name food type near near area area
inform inform inform inform inform inform inform i...
Báo cáo khoa học: "Parsing with Treebank Grammars: Empirical Bounds, Theoretical Models, and the Structure of the Penn Treebank" ppt
... is of-
ten done in parsing work (Collins, 1997, etc.). For
1
Effectively “testing on the training set” would be invalid
if we wished to present performanceresultssuchas precision
and recall, but ... capture the varying
magnitudes and exponents seen for different grammar
encodings and tree transformations. Since the
term
of comes directly from the number of start,
split, and end...
Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases pot
... KIM-containing PTPs). In addition, specific isoforms within
subtype families may contain additional protein domains and ⁄ or targeting sequences (e.g. the ER anchoring tail in PTP1B and the nuclear
localization ... than
dephosphorylation. Elegant work in cell models pro-
vided an intriguing two-way mode of action in which a
‘substrate-binding’ PTP combines phosphorylation-
depend...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... but in concert with a
number of conserved domains, including a GTPase
domain. Multidomain proteins that encode functional
kinase domains often utilize intrinsic protein kinase
activity distinct ... mechanisms
for LRRK2- mediated cell death and kinase activation are proposed. As a
promising target for neuroprotection strategies in PD, in vitro and in vivo
models that accur...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... complex proteins (ROC), C-ter-
minal of ROC (COR), mitogen-activated protein
kinase kinase kinase and WD40 domains. The presence
of the four protein–protein interaction domains
(ARM, ANK, LRR and WD40) ... WD40
domain. Because WD40 domain is involved in mediat-
ing protein–protein interactions, the LRRK2 G2385R
variant may impact on interactions with substrates
and ⁄ or regulatory p...
Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc
... proteins,
PFK2, TDH3, GPM1 and -3, ENO2, PDC5 and
ADH6 showed interaction with the yeast E3 ubiquitin
ligase RSP5 in a binding assay using protein chips [44].
For PFK, GPM, PDC and ADH this is in ... ubiquitin-activating enzyme (E1),
ubiquitin-conjugating enzyme (E2) and ubiquitin pro-
tein ligase (E3). E3 ubiquitin ligase binds directly to
the substrate proteins and thereby r...
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