Báo cáo khoa học: Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues ppt
... All of the tumor types were confirmed
by pathologic analysis. The experiments were undertaken
with the understanding and written consent of each subject.
The study methodologies conformed to the ... After incubation for 24, 48 and
72 h, the cells were incubated with 20 lL of MTT (at a
final concentration of 0.5 mgÆmL
)1
)at37°C for 4 h. The
medium was removed an...
... ends, and in particular at
the barbed end [23]. On the other hand, Pi has a negli-
gible effect on the critical concentration for polymeriza-
tion of F-actin in the presence of ATP, because of the
protective ... digestions of F-actin revealed that after
30 s incubation with cofilin at pH 8.0 the rate and
the extent of actin cleavage was the same in the
presenc...
... completing the catabolism of the pyrrolidine moiety of nicotine.
Expression of the genes of these enzymes was dependent on the presence of
nicotine in the growth medium. Thus, two enzymes of the nicotine ... expression of these genes
depends on the presence of nicotine in the growth
medium and we have determined the enzyme activities
of the proteins. O...
... 7. The arrows
labeled (b) and (c) point to the areas of interaction between the transmembrane helix of subunit 8 and helices G and H1 of cytochrome b and
between the N-terminus of subunit 8 and ... panels A and B and the relative amounts of each of the subunits determined by densitometry scanning of the stained Western
blots of the q° and CKL57...
... thus on the one
hand fully support these previous findings and on the other
hand extend them by far and set them in a more general
context, as both a-subunits of P4h, PDI as the b-subunit of
P4h ... clear twofold increase of PDI mRNA,
a more moderate increase of the mRNAs for prolyl
hydroxylases, and did not increase the mRNA abundance
of the other enzymes.
Discus...
... activation of Ga
16
and Ga
q
subunits. Therefore the lack of change in the rate of
degradation cannot be due to lack of receptor-activa-
tion of the alpha subunits.
Given that the activation of G proteins ... immunoprecipitates and the
arrowheads indicate the position of Ga
q
and
Ga
16
. The molecular mass standards are
indicated. The arrow indicates the...
... chelators on the
uptake and fate of NTBI and to investigate the potential of
these chelators for therapeutic use in Fe overload diseases
and cancer chemotherapy. Desferrioxamine (DFO), the
only chelator ... reactions
essential for growth and proliferation, is uncertain. Hence, it
is of interest to investigate the uptake and metabolism of
NTBI in normal and canc...
... switch and alters the expression of the two
nuclear genome coded isoforms of CytOX V [10,32]. The
regulation of genes CytOX5a and CytOX5b, coding for the
two isofoms Va and Vb, parallels that of ... with the
latterexpressedinanO
2
and heme regulated manner.
In this study therefore, we investigated how O
2
modulates
the expression of mRNAs for CytOX subunits...
... represents a window of two
words to the left and four words to the right of the
candidate noun-noun sequence. Table 5 shows the
performance of the two classifiers for some of the
contextual feature ... between one and four words be-
fore and after the candidate compounds. We use
symbols
1
and
r
for left and right context, respec-
tively and number to de...
... critical for the survival of developing B lym-
phocytes and the maturation of spleen B cells [41–43].
Abnormal activation of NF-jB has been shown to be
a hallmark of the development and progression of ... Tec
transcription via the NF-jB signaling pathway. These
findings provide further insight into the transcriptional
regulation of the TFKs and the role of N...