... (RING finger, B-box, and coiled-coil) protein
was identified that belongs to the superfamily of zinc-binding
proteins and is specifically expressed in the gill of eel,
Anguilla japonica. Euryhaline ... B-box, and coiled-coil (RBCC) proteins are a
group of zinc-binding proteins that belong to the RING
finger family. They are so called because they have an
N-t...
... FEBS 3099
chymotrypsinogen numbering is indicated in parenthe-
ses) is the key contact point with TF [9–12]. A number
of loss -of- function mutations were identified in an ala-
nine scanning mutagenesis ... strongly in
favour of the former, can be identified by gain -of-
activity mutations. Site-directed mutagenesis at certain
positions in FVIIa has indeed resulted in molecules
w...
... ribotoxins.
Keywords: Aspergillus protein; cytotoxin; protein –lipid
interaction; ribotoxin; a-sarcin.
a-Sarcin is the best characterized member of a family of
fungal cytotoxic ribosome-inactivating ... catalysis by a-sarcin [19,20],
rendered proteins with no detectable activity against ApA
[20]. Cleavage of ApA by a-sarcin is a low-specificity
reaction requiring high amounts of pr...
... using original length of stay data and 2003
nursing day prices. Subsequently, total individual costs
of care during the first six months were computed by
holding the original ratio between inpatient ... point representing a cost sav-
ing of € 5,990 and a QALY gain of 0.51. The point esti-
mate for the ICER is €11,685 saved per QALY gained;
€14,211 and €7,745 saved per QALY gaine...
... critical
care departments during winter of 2009 in Turkey.
MATERIAL AND METHODS
In response to an outbreak of influenza A virus
infection in Mexico, Turkish Ministry of Health de-
veloped a case ... cases of pandemic
(H1N1) 2009 influenza is markedly different from the
disease pattern seen during epidemics of seasonal
influenza, in that many of those affected were...
... subfamily of the cytoch-
rome P450 (CYP) enzymatic system, is responsible for
the metabolism of tacrolimus [10]. Specifically; tacro-
limus is mainly metabolized by CYP3A4 and CYP3A5
enzyme isotype. ... The alleles A and
G are CYP3A5*1 and CYP3A5*3, respectively. Indi-
viduals carrying at least one CYP3A5*1 allele express
CYP3A5 protein whereas individuals homozygotes
for CYP...
... limit of detection of 28
IU/mL. Body weight measurement and laboratory
data were collected and compared at the beginning
and at the end of therapy. The Knodell scoring sys-
tem for liver biopsy ... combined
pegylated interferon alfa-2a or alfa-2b plus ribavirin.
Genotypes of HCV were defined using the Bayer
TRUGENE HCV Genotyping Test. Serum concentra-
tion of HCV RNA was...
...
administered in all patients. Pain scores, opioid demand and the length of stay in PACU were assessed in a blind
manner. Results: Post operative pain scores were significantly lower in the fentanyl and ...
12
vomiting and sedation score (0=awake, 1=mild, 2=sleepy
but awakable, and 3 = very sleepy) and the length of stay
in the PACU. The latter was decided by a phys...
... transforming non receptor tyrosine kinase activity [4],
and the finding of EGFR, the first receptor tyrosine kinase paved the way to the understanding of the
role and significance of tyrosine kinase ... mechanism of action of tyrosine kinase
Tyrosine kinases are enzymes that selectively phosphorylates tyrosine residue in different
substrates. Receptor tyrosine kinases are a...