Báo cáo khoa học: The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand pptx
Tài liệu Báo cáo khóa học: The unusual methanogenic seryl-tRNA synthetase recognizes tRNASer species from all three kingdoms of life pptx
... archaeal organisms [2,3] and to determine to what extent they follow the rules accountingforidentitiesinprokaryotesandeukaryotes[1,4,5].Inspiteof the universality of the genetic code, there are ... that two other methanogenicSerRSs with atypical amino acid sequences, one fromthermophile Methanococcus jannaschii and the other frommesophile M. maripaludis, recognize eukaryotic and bac-terial ... 2) can participate in the tRNA:tRNA association. There is the tetranucleotideGUAC in the D-arm of M. maripaludis tRNASer,whichmay anneal with the same stretch in another tRNASermolecule...
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Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... collagen receptor present in platelets and megakaryocytes. Itbelongs to the superfamily of immunoblobulin receptorsand is closely related to Fca receptor (FcaR) and naturalkiller receptor [1]. The ... flowcytometry using the GPVI-specific ligand convulxin andantibody to convulxin (Fig. 1A). COS/F1 or mutantversions in which the transmembrane arginine of GPVIwas mutated to alanine (COS/FA) or the ... responsible for binding to the ligand, and the othersubunit, the FcR c-chain, responsible for transmission of the signal within the cell.Studies of GPVI-deficient human [23] and murineplatelets...
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Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx
... inhibitor substrate analogueswere made with type 1 FPSs from human [11] and pro-tozoa [6,12], and some of the structures [e.g. FPS fromhuman (2F94 and 3B7L) and Trypanosoma brucei(2P1C and 2I19) binding ... directly touches the x-end of GGPP bound in the same subunit, whereas phenylalanine 108 suppliedfrom the other subunit exists in the proximity of the x-end [24].These results led to the hypothesis ... muchcloser to the geranylgeranyl chain than do V178 andD182 in a-helix E (Fig. 8A). Especially, D182¢ directlytouches the x-end of the geranylgeranyl-chain.Although V178¢ is not in direct contact with...
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Báo cáo khoa học: The viral SV40 T antigen cooperates with dj2 to enhance hsc70 chaperone function docx
... the presence of dj2, hsc70 bound mutTAg in an ATP-independent fashion (Fig. 1B, lanes 5 and 6).These findings led us to hypothesize that dj2 binds T antigen in an ATP independent manner and the resulting ... dj2. The reduced amounts of hsc70 bound to TAg prior to dj2 addition (lanes 1 and 5) are probably due to the fact that the binding affinity of dj2 to hsc70 is stron-ger. The possibility of an antagonistic ... as proteinfolding, translocation, degradation and the acquisitionof cell thermotolerance [1–4]. In order to performtheir functions, the hsp70s cooperate with a widerange of divergent proteins...
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Tài liệu Báo cáo khoa học: Secondary substrate binding strongly affects activity and binding affinity of Bacillus subtilis and Aspergillus niger GH11 xylanases docx
... significantimportance for XBS and XAN. The SBS in thesesingle domain xylanases may be an example of a veryefficient strategy that targets the enzyme towards asubstrate to anchor and feed it into the ... compared to a partially closed righthand [21]. The SBS are present in different regions of the GH11 xylanases. In the B. circulans xylanase andin XBS, the SBS is located on the ‘knuckles’ of the enzyme, ... mutated to Ala aiming to investigate their impor-tance. Several mutations were also combined to assess the importance of the SBS as a whole for the biochem-ical properties of XBS and XAN. In an...
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Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
... constants for interaction of the ECD of BMPR-IA with the growth factors. Association (ka) and dissociation (kd) ratesfor the ligands with the ECD and the apparent dissociation con-stants ... type I receptor molecules are bound by the dimeric ligand. Subsequently, two type II receptor molecules arerecruited by the ligand type I receptor complex. Thisassociation initiates the p38–MAPK ... phosphorylation. The data presented here suggest that the pro-domain of BMP-2 can alter the signalling properties of the growth factorby modulating the ability of the mature part to interact with the receptors.Structured...
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Tài liệu Báo cáo khoa học: The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo pdf
... 2009)doi:10.1111/j.1742-4658.2009.07023.xRetinoic acid receptor (RAR) and retinoid X receptor are ligand- inducedtranscription factors that belong to the nuclear receptor family. The receptors are activated by small hydrophobic ... conformational changes ofboth RARa and RARbAs S-4o9cDH-RA induced retinoid receptor- dependentgene transcription, we wanted to investigate whether the metabolite could bind to these receptors. Ligand bind-ing ... acid receptors (RARs) and retinoid Xreceptors (RXRs) (reviewed in [8,9]). RARs and RXRsare ligand- dependent transcription factors, whichbelong to different subfamilies of the nuclear receptors(I...
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Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
... phosphorylationrestored full maturation of the K650M receptor to asignificant degree. To firmly establish that SU5402allowed the K650M receptor to be transported to the plasma membrane and endocytosed, ... that the 130 and 115 kDa bands (or 144 and 129 kDabands in the X807R mutant) corresponded to differ-ently glycosylated forms of the receptor, immunopre-cipitated wild-type and mutant receptors ... cellstransfected with the X807R mutant were immunoprecipitated with an anti-FGFR3 serum and the immune complexes were treated with endo H or PNGase as indicated prior to immunoblotting with an anti-FGFR3...
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Tài liệu Báo cáo khoa học: The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression ppt
... maybe essential to ensure the tight control of NTHi-induced TLR7 up-regulation and the resultant hostantiviral response. We can further speculate that the CYLD-dependent autoregulatory feedback ... submerged for the first 7 days and then the air ⁄ liquid interface was created by removing medium from the apical compartment of the cultures. The culturemedium was changed every other day until the air ... and quantified using an ABI 7500 sequence detector and the manufacturer’s corres-ponding software (7000v1.3.1; Applied Biosystems). The rel-ative quantities of mRNAs were obtained by using the comparative...
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Báo cáo khoa học: Estrogen-related receptor a and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria potx
... indicating that other regulatory fac-tors are implicated in the coordination of the expres-sion of the nuclear and mitochondrial genomes.ERRa is an orphan nuclear receptor that binds to the ERR response ... XCT790.XCT790, an artificial synthetic compound, is known to interfere specifically with the ligand- binding domain ofERRa without affecting estrogen receptor signalling[26], and to induce the degradation ... receptor a (ERRa) andnuclear respiratory factors 1 and 2, are associated with the coordination of the transcriptional machinery governing mitochondrial biogenesis, whereascoactivators of the...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ