... between
donor and acceptor dyes, will therefore unveil the sta-
tus of physical union and separation of complementary
strands during renaturation and strand exchange,
respectively, and thereby assesses the ... monitor the
time course of renaturation and strand exchange activ-
ities of OsDmc1. The renaturation activity was found
to be stimulated in the presence o...
... the antiviral
activity and retained the binding efficacy. The flexibility of
the target molecule complicates the prediction of an effect
caused by a modification on the inhibitor and necessitates
structural ... surf ace and has
polarity d ifferences. This is documented by the threefold
improvement in activity of inhibitors 2 and 6 against the
triple mutant M46I,...
... preferential hydration of the
protein domain is the driving force of protein stabiliza-
tion or folding [3,4]. Furthermore, the effect of
osmolytes on the functional activity of an enzyme has
also ... published elsewhere. We have
therefore measured the thermodynamic parameters of
RNase-A in the presence of these amino acids and
amino acid derivatives, and values...
... phosphorylation of dHAND
decreased the transcriptional a ctivity of dHAND/E47
heterodimer.
Fig. 6. The effects of A kt expression on the transcriptional activity of dHAND. (A) AU5-d HAND, -dHAND-Ala-X, -dHAND-Ala, ... phosphorylation of these sites might affect the DNA
binding and/ or dimerization activities of dHAND. We first
analyzed the effect of phosphorylation on...
... second number then we multiply two numbers together
•
Press the = key. Answer : 2.232710263
We continue to delete the digit 2 at the first number and the
digit 7 at the second number then we multiply ... 1
The number contains the end two digits are digit 1
The number contains the end three digits are digit 1
The number contains the end four digits are digit 1
Answer...
... (black) and sucrose (grey).
Doc. S1a. Model structure of C24.
Doc. S1b. sbml format of model structure of C24.
Doc. S2a. Model structure of Rsch.
Doc. S2b. sbml format of model structure of Rsch.
Doc. ... concentration c
A
(t) and the rate constant k.
The model code and a detailed description of the model
structure are provided in Docs S1a, S1b, S2a,b and S3)....
... cooperative
binding of Ca
2+
turns the N-terminal part of the Gla
domain inside out, exposing the hydrophobic x-loop
to solvent and burying the majority of the Gla resi-
dues. Of the seven Ca
2+
, the majority ... of bovine prothrombin fragment 1
in complex with Ca
2+
[41], the 10 ⁄ 12 site resides near
the x-loop and the linear array of bound calcium ion...
... membrane. Together, our findings contribute
to the understanding of the role of KCNE4 as a
potentially important regulator of KCNQ1 and other
K
V
channels.
Results
Characterization of KCNE4 antibody
A ... KCNE
proteins, and the overlapping expression patterns of
these subunits [22], there may be multiple and diverse
KCNE–KCNQ1 interactions within the same cells or
tissu...
... RT-PCR to study the tissue-specific use of
each promoter. We show the translation initiation site
of isoform 2 and different intracellular distribution of
isoforms 1 and 2, and discuss the regulatory ... part of isoform 2 mRNA. The third
exon, exon 1c, extended from +1379 to +1454. The
noncoding exons of exons 1a and 1c contributed to the
5¢ nontranslated region...
... alog (pH )
pK
a2
), Lim1 is the lower limit of the curve, Lim 2 is the
middle limit of the curve and Lim 3 is the upper limit of the
curve.
Stopped-flow kinetic studies of the oxidative
half-reaction ... group on Trp57 of the small
subunit to a carbonyl group, and (c) insert a second
oxygen atom into the TTQ ring [11]. The essential nat-
ure of some of th...