Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrod

Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot

... PRIORITY PAPER Epoxidation of benzo[ a ]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane Pyotr Kisselev 1, *, ... correlation between the activation of the CYP1A1- catalyzed epoxidation reaction of 7,8-diols a nd the enhanced nonbilayer phase propensi ty in...

Ngày tải lên : 08/03/2014, 10:20

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Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx

... We initialize the sampler by randomly as- signing each string in the training corpus a random tree generated by the grammar. Then we randomly select a string to resample, and sample a parse of ... grammar, in which the subtrees are speciﬁed in advance, in an adaptor grammar the subtrees, as well as their probabilities, are learnt from the training data. In orde...

Ngày tải lên : 20/02/2014, 09:20

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Báo cáo khoa học: Testosterone 1b-hydroxylation by human cytochrome P450 3A4 pdf

... baculovirus-infected insect cells contain- ing 4 pmol of P450 3A4. (Varying amounts of P450 were used because of differences in rates of the systems, in order to maintain linearity of product formation vs. ... ay as one of the characteristic assays of P450 3A4, which was subsequently shown to be the most abundant P450 in human liver and small intestine [ 22] and...

Ngày tải lên : 07/03/2014, 16:20

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Báo cáo khoa học: "Learning to Win by Reading Manuals in a Monte-Carlo Framework" pot

... baselines – on average winning 53.7% of all games within the ﬁrst 100 steps. The dismal performance, on the other hand, of both the random baseline and the game’s own built -in AI (playing against ... yielding a 27% absolute improvement and winning over 78% of games when playing against the built- in AI of Civilization II. 1 1 Introduction In this paper, we study...

Ngày tải lên : 07/03/2014, 22:20

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Báo cáo khoa học: PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans doc

... (a) they occur ex vivo in human liver cell lines and in vivo in human plasma; (b) in the case of the propeptide, phosphorylation is decreased in the naturally occurring ‘loss -of- function’ R46L and ... autocatalytic processing of its prodomain in the endoplasmic reticulum and that its inhibitory prosegment remains associated with it following secretion. Here...

Ngày tải lên : 16/03/2014, 06:20

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Báo cáo khoa học: Myocyte enhancer factor 2B is involved in the inducible expression of NOX1⁄ NADPH oxidase, a vascular superoxide-producing enzyme ppt

... arrows. (B) The exon ⁄ intron structure of the NOX1 gene and its splicing pathway. Open boxes indicate exons. Numbers in the box denote the size of each exon (bp). The size of the intron is indicated ... affect the mobility of the speciﬁc bands (lane 4, Fig. 4B). These results suggest that PGF 2a increases the binding of MEF2 to the consensus-binding site loc...

Ngày tải lên : 30/03/2014, 03:20

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Tài liệu Báo cáo khoa học: Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural speciﬁcity variants doc

... FEBS bean and soybean. When binding of arginine in the presence of tRNA was investigated, some changes in the binding architecture were observed [35], in that N(153:Y), in addition to interacting with ... arginylated in the presence of arginyl-tRNA synthetase from jack bean (diagonal shading) or soybean (vertical shading), and the level of charging was compared w...

Ngày tải lên : 18/02/2014, 13:20

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Tài liệu Báo cáo khoa học: "Enhanced word decomposition by calibrating the decision threshold of probabilistic models and using a model ensemble" pdf

... into training and test subsets with the ratio of 9:1 we randomly split the data into training, validation and test sets with the ratio of 8:1:1. We then run our experiments and measured contingency ... Hafer and Weiss, 1974). Another way of classifying ap- proaches is based on the learning aspect during the construction of the morphological model. If the data for...

Ngày tải lên : 20/02/2014, 04:20

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Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf

... altering the geometry and protonation state of the residues involved in catalysis and inhibitor binding, and (b) limiting the allosteric effects triggered by sodium binding. X-ray structures of human ... simulation of DK9 thrombin in explicit water solvent supports the role of the A-chain in affecting the conformation and catalytic properties of the...

Ngày tải lên : 07/03/2014, 12:20

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Báo cáo khoa học: Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae doc

... intracellular maturation of CCK-22 was investigated in an in vitro protease assay using a c rude extract of S. cerevisiae to analyse the processing of synthetic human CCK-33 to CCK-22 in the presence of different inhibitors. ... the Lys-speciﬁc processing of proCCK, or that the protease is attached to the outer membrane of the mitochondria with the N-termin...

Ngày tải lên : 07/03/2014, 16:20

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