Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
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Selecting cells with different Alzheimer’s disease c-secretase activity
using FACS
Differential effect of presenilin exon 9 deletion on c- and e-cleavage
M. Fleur Sernee
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of the suppression of beta-amyloid peptide secretion from cultured
cells with i...
... AR-JP, and 77% of
sporadic cases with disease onset before the age of 20
[2]. Clinically, PD patients with mutations in PARK2
suffer a slow progression of the disease commonly
associated with early-onset ... MM (2005) Interaction of DJ-1 with Daxx
inhibits apoptosis signal-regulating kinase 1 activity and
cell death. Proc Natl Acad Sci USA 102, 96 91 96 96.
29 She...
... Department of Molecular Neuroscience, Institute of Neurology, University College London, UK
5 Reta Lila Weston Institute and Department of Neurodegenerative Disease, Institute of Neurology, London, ... is the major component of
Lewy bodies and mutations in this gene are a rare
cause of PD. Only three point mutations have been
described to date, but duplication and triplicat...
... minor conformation of
APV showed one less hydrogen bond, one less C-HÆÆÆO
interaction and weaker interactions than the major
conformation had with PR.
Effects of mutations on PR structure and
interactions ... oxygen and the carbamate car-
bonyl oxygen of APV. The second conserved water
(H
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hydrogen bonds to the carbonyl of Gly27...
... hydroxylation of mono-
phenols and the oxidation of o-diphenols.
Different names are used for these activit-
ies, as shown in the Figure. One of the
most common monophenolic substrates is
tyrosine, and ... as a
function of the concentration of l-dopa cofactor added
to the assay mixture. R3-1501
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extracts have a high
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population(x
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tion of q.x
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an MR subtree under population, and, on the right,
state-variable pair q.x
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stands for ... left hand side of rule r and u its
right hand side. The transducer is linear iff no vari-
able appears more than once on the right hand side.
It is non-deleting iff all v...
... Definition. In Proceedings
of the Sixth Message Understanding Conference (MUC-
6).
MUC-7. 199 7. Coreference Task Definition. In Proceed-
ings of the Seventh Message Understanding Conference
(MUC-7).
V. ... implementation of the Lappin and
Leass’ ( 199 4) Resolution of Anaphora Procedure
(RAP). JavaRap resolves only pronouns and, thus,
it is not directly comparable to Reconcile. GuiT...
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Portland, Oregon, June 19- 24, 2011.
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... 11 79 11 89,
Portland, Oregon, June 19- 24, 2011.
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2011 Association for Computational Linguistics
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