Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... An arginyl in the N-terminus of the V
1a
vasopressin receptor is part
of the conformational switch controlling activation by agonist
Stuart R. Hawtin
1,
*, Victoria J. Wesley
1
, ... UK
Defining how the agonist receptor interaction differs from
that of the antagonist receptor and understanding the
mechanisms of receptor activation are funda...
...
trovert the meaning intended by the original. For the
purposes of this experiment, the question of the fidelity
of a translation was converted into the complementary
question of whether the original ...
hends the meaning intended.
1. Not informative at all; no new meaning is added nor is
the reader’s confidence in his understanding increased
or enhance...
... vessels). Indeed, the vascular network of the brain
is predominantly formed by angiogenesis. During this
Keywords
astrocyte; barriergenesis; blood–brain
barrier; brain angiogenesis; endothelial ... endothelial cells elim-
inate the effects of the basement membrane and
differences in the luminal–abluminal polarity of the
endothelium. To bridge the gap between in vit...
... suggesting that this peptide may also
affect the development of the wing disks at the prepu-
pal stages. It is interesting to note that bombyxin-II
also stimulated the growth of the wing disks in the
butterfly ... the input and the eluate of the chromatography
were resolved by Tricine ⁄ SDS ⁄ PAGE and then analyzed by Coo-
massie Brilliant Blue staining (left) a...
... mixture) in most cells analysed, indicating the
ionotropic nature of the response.
We further characterized the presence of functional
P2X7 receptors by testing the effect of the P2X7 antag-
onists ... for
15–30 min, depending on the antagonist
assayed. Traces represent mean ± standard
error of the mean from at least 150 individ-
ual cells. The inhibition of BzAT...
... and retinoid-binding pro-
teins between photoreceptors and retinal pigment epi-
thelium (RPE); it is essential for maintaining normal
vision [3,4]. The key step in the retinoid visual cycle is
the ... A1,
A2). Using this antibody, we examined the localization
of RPE65c in the zebrafish retina by immunohisto-
chemistry. An intense RPE65c signal was detected in
the in...
... and
C-terminal helices of the c ring, respectively. The
C-terminal helices show a clear handedness, and two
of the rings face in the opposite direction in the
membrane to the other two, forming the same pattern
as ... reconstituted c rings.
(A, B) Crystalline assemblies of c rings. Although the number of
subunits forming the rings can be seen, the signal-to-noi...
... HPLC traces
of animals in the first two weeks of lactation. The fraction
containing eugenin is indicated by an asterisk in Fig. 2.
Two further HPLC separations of the initial eugenin frac-
tion ... sulfate containing peptides
can be challenging because of possible hydrolysis of
the sulfate residue occurring during synthesis, in
Table 1. Eugenin, and mammalian and...
... compute the relatedness scores.
The information flow of the API is summarized by
the sequence diagram in Figure 2. The higher in-
put/output layer the user interacts with is provided
by a Java ... the bulk of querying ency-
clopedia entries to the MediaWiki software (which
in turn queries the database) and efficiently parsing
the text responses into structu...
... in- car” information sys-
tem). Then we describe the major components of the
system and give examples of their use. We then discuss
the important features of the system in respect to the
dialogue ... 2005)).
This agen t can be called whenever the system has
to decide on the next dialogue move. In the original
hand-co ded system this decision is made by way of a...