Báo cáo khoa học: Structure of amyloid b fragments in aqueou

Báo cáo khoa học: Structure of amyloid b fragments in aqueous environments docx

... other Ab fragments, including full- length Ab. The two most abundant forms of Ab are the 40 and 42 residue peptides, Ab 1)40 and Ab 1)42 . Both forms are capable of assembling into b- sheet ﬁbrils. However, ... [13–15]. The study of hydrogen–deuterium exchange mapping of Ab using NMR revealed that the middle of Ab is involved in a b structure ...

Ngày tải lên : 07/03/2014, 12:20

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Báo cáo khoa học: "STRUCTURE OF SENTENCE AND INFERENCING IN QUESTION ANSWERING" docx

... then it can be stated that the root of every tree of the mentioned kind is labelled by a symbol the lexical part of which belongs to the word class of verbs. The kinds (and to a certain part ... to be used for another set of tasks, including the anal- ysis of a broader set of input texts, questions, etc.); (b) linguistic meaning is ~...

Ngày tải lên : 24/03/2014, 05:21

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Báo cáo khoa học: Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers pot

... Increase epi-Inositol b- Sheet No effect Inhibits Inhibits Inhibits L-epi-1-Inosose Partial b- sheet No effect No effect No effect Increase L-epi-2-Inosose Strong b- sheet < Control Inhibits Inhibits Inhibits allo-Inositol ... that allo-inositol is a kinetic inhibitor of Ab42 ﬁber formation but is unable to fully inhibit ﬁber formation. These results further suggest that allo-i...

Ngày tải lên : 16/03/2014, 06:20

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Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... Grubb A (2004) Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disul- fide bridges, antibodies, and carboxymethylpapain to stabilize ... that the b- sheet spine in amyloid fibrils of b 2 -microglobulin could be made from amyloidogenic peptide sequences of the hinge regions o...

Ngày tải lên : 14/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

... Tyr42 (in RNase T1) or an arginine (in RNase Sa, barnase, and binase) has an important role in closing the guanine-binding site [10,15–17]. How- ever, although the interactions between guanine and the ... molecules, guanosine formed the high- est number of hydrogen bonds of all the bases, up to ﬁve, and had the best ﬁt into the base-binding site. In addition, guanine under...

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

... by a two-step mechanism in which the N-terminus of the inhibitor ﬁrst binds to the enzyme, displacing the occluding loop, followed by the binding of another two loops of the inhibitor [24]. Besides ... FEBS Friguet et al. [30] and was found to be 2.7 ± 1.8 nm, depicting a strong interaction between 2A2 mAb and cathepsin B. Determination of the 2A2 mAb binding s...

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR docx

... properties, thereby providing a broad binding speci- ficity. In some proteins containing tandem homologous domains, inter-domain interactions fix the relative ori- entation of the domains in a specific ... and boxes (blue for the N-terminal domain; red for the C-terminal domain) indicate some of the perturbed resonances. M. Takeda et al. SAIL-NMR structure of a my...

Ngày tải lên : 18/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Cleavage of nonphenolic b-1 diarylpropane lignin model dimers by manganese peroxidase from Phanerochaete chrysosporium Evidence for a hydrogen abstraction mechanism docx

... amount of substrate remaining was quantitated by HPLC as described in the text and in the legend to Table 1. 286 G. V. B. Reddy et al. (Eur. J. Biochem. 270) Ó FEBS 2003 conducted in the absence of ... was oxidized. In addition, while about 30% of the diarylpropane VI was oxidized in the presence of Tween 80 during the 12 h incubation, in the absence...

Ngày tải lên : 20/02/2014, 23:20

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Tài liệu Báo cáo khoa học: Structure of peptidase T from Salmonella typhimurium doc

... roteins as well as amastatin bound to LAP a s d iscu ssed in the text . Ó FEBS 2002 Structure of peptidase T (Eur. J. Biochem. 269) 447 Substrate binding Structural investigation of enzyme±ligand complexes ... substrate bindin g site has been m apped based on our knowledge of the structures of leucine aminopeptidase (LAP) and APP [18,19]. It has been point...

Ngày tải lên : 21/02/2014, 03:20

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Báo cáo khoa học: Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy ppt

... homodimer of a single-transmembrane polypeptide, each containing an extracellular ANP- binding domain (ECD), a transmembrane domain, and an intracellular domain consisting of an ATP-binding regulatory ... juxtamembrane domains in response to ANP binding. Looking down- wards toward the cell membrane, ANP binding causes a translation of the juxtamembrane domains from t...

Ngày tải lên : 07/03/2014, 03:20

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