... in Fig. 2. In the absence of MgCl2, the affinity of Fpg for the THF :C ligand was 1.6-fold higherthan for the THF:A ligand. The presence of Mg2+hadlittle effect on the binding of Fpg to the ... no Mg2+ (C ⁄ A specificity of 1.5 for DNA glycosylase reaction and 0.78 for APlyase reaction) and the increase in the preference for 8-oxoG :C with increasing salt (C ⁄ A specificity of 8.6 for ... concentrations of KCl and MgCl2. (A C) Fpg, (D–F) glycosylaseactivity of OGG1, (G I) AP lyase activity of OGG1. The extent of cleavage of 8-oxoG :C (A, D, G) or 8-oxoG:A (B, E, H) or the C ⁄ A specificity (C, ...