Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx

Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx

Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx

... in the product chain length determination mechanism of type II GGPS. Moreover, this result suggests that the other subunit of the homooligomeric enzyme is involved in the product chain length determination mechanism. ... information on the product determination mecha- nism of type II GGPS. (A) The direction of the geranylgeranyl chain...
Ngày tải lên : 07/03/2014, 06:20
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Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx

Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx

... similar arrangement, and the side chain of Ser97 in VPRK is too short. One side of the loop is involved in the bind- ing of the P2–P4 residues of a substrate. The other side of the loop is close to Arg94 ... considered to display differences in the fold of the main chains. None of these includes any of the binding sites, but some are located in the vicini...
Ngày tải lên : 19/02/2014, 07:20
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Tài liệu Báo cáo khóa học: The PAS fold A redefinition of the PAS domain based upon structural prediction ppt

Tài liệu Báo cáo khóa học: The PAS fold A redefinition of the PAS domain based upon structural prediction ppt

... To overcome the fact that the prosa z-score is dependant of the length of the amino acid sequence, the z-score was normalized using the natural logarithm of the sequence length [39]. The resulting ... distribution of the percentage best model, for each of the 672 best models, is presented in the left panel. Of the six template structures used, 54% of...
Ngày tải lên : 19/02/2014, 12:20
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Báo cáo khoa học: The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity pot

Báo cáo khoa học: The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity pot

... changed either in the presence or absence of the metal cofactor. By contrast, the sub- strate binding affinity of the RNase H domain proba- bly increases in the presence of the metal cofactor compared ... sequences of the oligonucleotides cleaved by the enzyme are shown. The differences in the lengths of the arrows reflect relative cleavage intensities at the p...
Ngày tải lên : 06/03/2014, 22:21
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt

Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt

... Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis. J Biol Chem 276, 47474–47482. Product chain length of ... the length of prenyl products, indicating a requirement for insertion of specific amino acid residues for lengthen- ing the ultimate product chain. Moreo...
Ngày tải lên : 19/02/2014, 07:20
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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

... G 4 and the sidechain of Asn122. In the second model (Fig. 1B) the structure of the hexanucelotide is, on the whole, unchanged and the majority of the interactions that were seen in the first ... attributed solely to the change in charge and size of the sidechain of this single residue, the crystal structure of RTA N122A was solved. The RMSD from the C a a...
Ngày tải lên : 19/02/2014, 12:20
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Tài liệu Báo cáo khoa học: Electron transfer chain reaction of the extracellular flavocytochrome cellobiose dehydrogenase from the basidiomycete Phanerochaete chrysosporium doc

Tài liệu Báo cáo khoa học: Electron transfer chain reaction of the extracellular flavocytochrome cellobiose dehydrogenase from the basidiomycete Phanerochaete chrysosporium doc

... of propionates of heme, was mutated to Tyr, and the thermodynamic and kinetic properties of the mutant (F166Y) were compared with those of the wild -type (WT) enzyme. The mid-point potential of ... because of the weaker domain interaction of this mutant enzyme. The F166Y mutant is, however, useful for monitoring the electron transfer step of CDH, because the...
Ngày tải lên : 19/02/2014, 18:20
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Tài liệu Báo cáo khoa học: The resident endoplasmic reticulum protein, BAP31, associates with c-actin and myosin B heavy chain Analysis by capillary liquid chromatography microelectrospray tandem MS ppt

Tài liệu Báo cáo khoa học: The resident endoplasmic reticulum protein, BAP31, associates with c-actin and myosin B heavy chain Analysis by capillary liquid chromatography microelectrospray tandem MS ppt

... loss of these interactions even though the amounts of cellular crBAP31 and c-actin did not apparently change (Fig. 5B). These findings, coupled with the strong enrichment of the c-isoform of actin ... have arisen at the genetic level (by the presence of two or more allelic copies of the gene of interest) rather than by the presence of low-level amount of contami...
Ngày tải lên : 20/02/2014, 23:20
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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"

Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"

... During the monitoring period, details of the total number of all prescribed drugs on each day were recorded. MEs were assessed by type and patient outcome. The type of error was categorised by the ... (where the patient received the drug). The intercepted errors were scored separately on the basis of their possible impact on the patient, if the prescription had...
Ngày tải lên : 25/10/2012, 10:39
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Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"

Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"

... intravenous lines). The observers were not involved in the daily care of the patients, and ICU physicians were not aware of this part of the observation. As a consequence, the clinical relevance of the predefined ... for other infections, and the absence of radiological signs of pulmonary congestion might have resulted in another fluid therapy regimen. We did not sco...
Ngày tải lên : 25/10/2012, 10:39
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