... respectively. These
variations of the ratios of the metabolites suggest modifi-
cations in the catalytic mechanism responsible for the
metabolism of DDT.
Substrate binding
The substrate induced binding ... mutated
positions in CYP6A2 (helix J and vicinity of the b sheet 3–3).
These results are also original because this is the first
description of the role of mut...
... production of inter-
leukins and secretion of immunoglobulins on the
mucosal surface of the intestine [49,50]. The antibacte-
rial defence of the intestinal mucosa depends in part
on stimulation of CCK ... euge-
nin, indicating that eugenin is indeed acting through
CCK
2
receptors.
To further investigate the interaction of eugenin with
CCK
2
receptors, we investigated...
... terminal in the grammar. If A
is a terminal then G
A
is the distribution that puts all
of its mass on the unit tree (i.e., tree consisting of a
single node) labeled A. If A is a nonterminal then
G
A
is ... parse of that
string with a PCFG approximation to the adaptor
grammar. This PCFG contains a production for each
adapted subtree in the parses of the other strings i...
... that the RPEL domain of MRTF-A binds
actin more strongly than the RPEL domain of myocar-
din, and that the RPEL motif itself is an actin-binding
element. RPEL1 and RPEL2 of myocardin bind actin
weakly ... as
STARS-interacting proteins. These novel proteins con-
tain four LIM domains and a C-terminal villin head-
piece domain, which mediates actin-binding in several
proteins, suc...
... suggesting the role of miR-9 in the growth
inhibition of malignant cells.
The fundamental function of miRNA is to regulate
their targets by direct cleavage of the mRNA or by
inhibition of protein ... predicted in the TargetScan database, the NF-jB1
3¢-UTR carries a miR-9 binding site. The NF-jB1 3¢-UTR mutation containing a mutated miR-9 ‘‘seed region’ binding site...
... (2009) 2–12 ª 2008 The Authors Journal compilation ª 2008 FEBS
MINIREVIEW
Post-ischemic brain damage: the endocannabinoid system
in the mechanisms of neuronal death
Domenico E. Pellegrini-Giampietro
1
, ... ischemia. The results of
these studies have been rather conflicting in supporting either a beneficial
or a detrimental role for the endocannabinoid syste...
... peroxynitrite
(ONOO
)
). These findings indicate that the cysteine
residues exposed on the surface of proteins are the
dominant intracellular thiol and that they may play an
important role in intracellular ... number of
studies have investigated the intracellular abundance of
protein thiols [2,5–8], little is known about the amount
of exposed protein thiols within cells in...
... attack of
the L-hOrn
3
a-amino group onto l-haOrn
4
. Taking
into account that the synthetases involved in the bio-
synthesis of the DKP-inheriting toxins thaxtomin
and fumitremorgin also contain ... domains,
suggesting the function of an initiation module mediat-
ing the condensation of an external building block
with the PCP-tethered substrate. Module 4 contains a
C-...
... specifically
inhibits PTP opening by binding to cyclophilin D in
the matrix and on the inner surface of the IM [51–54].
Growing evidence has implicated MPT in the necrotic
and apoptotic death of hepatocytes ... decreasing
the activity of caspase-3 in the three cell lines.
Effect of HSS knockdown on CCCP-induced
apoptosis
To further elucidate the functional role o...
... dfla
tren tinh tfldng trd, tinh anh em, tinh
yeu.
62
Nghien
ciiu
Kinh
tSsd370
-
Thang
3/2009
Ban chd't cua cuoc khung khoang
cdng
bIng,
tfl do
va
binh
ding.
CNXH the ky
XXI ... cac the che tao nen sfl phu
thudc tinh
thin va
vat cha't.
Sfl thd'ng tri cua Washington dang KH.
Phai tao cac the che thd'ng nha't mdi ciia
Chau My Latinh ve chi...