... cAMP response element-binding protein (CREB) is imported
into mitochondria and promotes protein synthesis
Domenico De Rasmo
1
, Anna Signorile
1
, Emilio Roca
1
and Sergio Papa
1,2
1 ... of CREB, cAMP and cPKA on mitochondrial protein synthesis. Mitochondrial protein synthesis was performed in a rat liver
mitochondria suspension in the presence of [...
... dehydrogenation and is hard to reconcile with a
particular structure. It should be pointed out that only the
peaks with m/z 135.1 and 132.1 are consistent with only the
N
1
- and not the N
5
-isomer, and ... French].
16. Qiao, C. (2004) New copper amino oxidase probes: synthesis,
mechanism and enzymolo gy. PhD Thesis, Case Western Reserve
University, Cleveland, OH.
17. Torchy, S...
... but the distance
between Od2 of Asp209 and Ng2 of Arg344 is only
10.2 A
˚
.InTliTMBP, the cleft is the smallest among
the three proteins (Fig. 7C). The ligand, trehalose,
is half-buried, and the ... sugar-binding protein family was found to be
located upstream of the TVA II gene, and the affinities
of this protein for c-CD were higher than that for
maltose [7]. The results sugg...
... appear to cause amyloidosis, but
Keywords
amyloidosis; lysozyme; protein degradation;
protein folding; protein secretion
Correspondence
C. M. Dobson, Department of Chemistry,
Lensfield Road, University ... expression of the recently discovered F57I
and W64R lysozyme variants from P. pastoris resulted
in yields of 0.04 and 0.3 mgÆL
)1
, respectively, based
on UV–visible (UV-vis) spect...
... binding affinity of this site is in the milli-
molar range, which is considered to be physiologically
relevant, and that this signal is then transmitted to
TnrA.
BIAcore analysis of the GS–TnrA interaction
The ... nitrogen-
limited conditions [13]. GlnK consists of three 12-kDa
monomers, and is a small regulatory protein that
belongs to the PII protein family. GlnK homologs
bin...
... and II
(IGF-I and -II) and their affinity for these ligands is
modulated by several mechanisms: attachment to the
extracellular matrix and post-translational modifica-
tions, such as proteolysis, ... during gestation and, as a modula-
tor of insulin-like growth factors or by independent mechanisms, regulates
embryonic implantation and growth. The protein is phosphorylated and...
... Sigma,
Zwijndrecht, the Netherlands) in 50% of mixture B into the
ESI-TOF-MS after the gradient had finished.
Acknowledgements
Martijn Pinkse, Akira Honda, Sander Engels and
Christian Nickl are kindly ... 272, 10522–10528.
14 Reed RB, Sandberg M, Jahnsen T, Lohmann SM,
Francis SH & Corbin JD (1996) Fast and slow cyclic
nucleotide-dissociation sites in cAMP- dependent protein
kinas...
... established on this
drug was admitted to the ICU. Although we did not prospec-
tively look for all missed prescriptions, standard care was for
the pharmacist to review admissions and note discrepancies
between ... and this may have affected the results. Ideally, the
impact of this could be minimised by sampling over a longer
period and more frequently, but this was beyond the scope
and...
... with increased risk of cardiovascular disease, the leading cause of
death. Therefore, it is important to understand the molecular basis underly-
ing obesity and related metabolic diseases in order ... signal
sequence in the N-terminus and ANGPTL6 ⁄ AGF
protein is detected in the circulation, indicating that
it is secreted [9,13]. ANGPTL6 ⁄ AGF induces angio-
genesis and arteriog...
... SR
(serine- and arginine-rich proteins) family of splicing
factors. CAPER, a SR-like protein, interacts with ERa
and the progesterone receptor and modulates the
ligand-dependent transcription and alternate ... regulation and mixed lineage
leukemia.
Acknowledgements
We thank Imran Hussain, Sahba Kasiri, Bishakha
Shrestha, Saoni Mandal and other Mandal lab mem-
bers for useful disc...