Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt

Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt

Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt

... polyQ and polyQ-expanded Huntingtin formed immobile inclusions in the cytosol and in the nucleus [20]. Thus, there are at least two types of inclusions – mobile inclu- sions and immobile inclusions ... glutamine residues in healthy individuals, whereas they are expanded to more than 40 repeats in patients. In the polyQ diseases, inclusions containing polyQ- expanded...
Ngày tải lên : 06/03/2014, 09:22
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... differentiation was initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum. Cells were fixed on day 4 of differentiation and stained with hematoxylin and eosin. ... control was maintained in a standard incubator with 21% O 2 . The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of...
Ngày tải lên : 18/02/2014, 08:20
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Báo cáo khoa học: Amyloid oligomers: formation and toxicity of Ab oligomers ppt

Báo cáo khoa học: Amyloid oligomers: formation and toxicity of Ab oligomers ppt

... M (2004) Kinetics and binding sites for interaction of the prefol- din with a group II chaperonin: contiguous non-native substrate and chaperonin binding sites in the archaeal prefoldin. J Biol ... death and blocked LTP. The finding of ADDL in soluble brain extracts from the human AD brain using ADDL-specific antibody supports the idea that the existence of ADDLs in the...
Ngày tải lên : 06/03/2014, 09:22
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Báo cáo khoa học: Amyloid oligomers: diffuse oligomer-based transmission of yeast prions ppt

Báo cáo khoa học: Amyloid oligomers: diffuse oligomer-based transmission of yeast prions ppt

... this context, the amyloids that are used in the prion should be fragile. Understanding, in greater detail, the intrinsic fragility of the amyloids and their susceptibility to trans-acting factors, ... in the cells after the foci disappeared. The live-cell imaging showed the appearance of the foci in the daughter cell at almost same time as when the foci re-appe...
Ngày tải lên : 06/03/2014, 09:22
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Báo cáo khoa học: Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states docx

Báo cáo khoa học: Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states docx

... structure. The situation is, in some respects, similar to the situation of studying protein folding and dynamic protein–protein interactions, such as in the case of chaperone action. Restricting us ... twofold: the necessity of a cysteine-scanning approach; and the intrinsic bulkiness and hydrophobicity of the pyrene label. Modern fluorescent techniques and novel spectr...
Ngày tải lên : 06/03/2014, 09:22
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Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx

Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx

... nuclei within the same cytoplasm. One is the germinal micronucleus and the other is the somatic macronucleus. These nuclei both originate from a ferti- lized micronucleus (synkaryon) during conjugation [14,15]. ... caspase-8- and caspase-9- like activities, which appear to be involved in the final resorption of the parental macronucleus during PND in T. thermophila, and s...
Ngày tải lên : 20/02/2014, 03:20
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Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot

Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot

... Italy Introduction Towards the end of the 1970s, in the beginning of pre-mRNA splicing research [1,2], defining exons and introns was essentially based on observing the final composition of the mature ... J (2006) A splice- supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing...
Ngày tải lên : 06/03/2014, 09:22
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Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx

Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx

... lack of DNA binding. Indeed, in the case of War1-42p, in vivo footprinting data (Fig. 5) indicate an inability to bind to the WARE, which is normally decorated by wild-type War1p in the presence ... expressed and properly localized in the nucleus, the War1-42p variant fails to bind the weak-acid-response elements in the PDR12 promoter, as shown by in vivo footprin...
Ngày tải lên : 19/02/2014, 00:20
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Tài liệu Báo cáo khoa học: "An Empirical Investigation of Discounting in Cross-Domain Language Models" ppt

Tài liệu Báo cáo khoa học: "An Empirical Investigation of Discounting in Cross-Domain Language Models" ppt

... negative when the n-gram occurs more in the test data than in the training data. Let W i = {w : k train (w) = i} be the set of n-grams with count i in the training corpus. We define the average ... configurations, training on NYT95 and testing on the indicated corpora. For each n-gram count k, we compute the average number of occurrences in test for all n-grams occurri...
Ngày tải lên : 20/02/2014, 04:20
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Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot

Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot

... representation /an- guages in order to focus on formally specifying domains and using ~hat specification in language processing rather than on defining new domain- independent representation ... supporting this hypothesis appear in [2, 13] for interpreting nominal compounds; in [6, 7, 29], for common sense reasoning about modifier attachment; and in [32] for phenomena in...
Ngày tải lên : 21/02/2014, 20:20
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