... application
of SH2 domain binding peptides, which results in
blocking of the binding of the SH2 domain to the
substrate and thereby preventing interaction of
the substrate with the kinase domain. For ... Y527F
D1)250
N-terminal, SH3, SH2,
kinase domain and C-terminus
Deletion of N-terminal, SH3 and
SH2 domain of kinase- dead n -Src
B. R. Groveman...
... embryo-
genesis and synthesis of in ammatory cytokines [43,52]
and is essential for S100A8 induction in macrophages
[27]. Inhibitors of the MEK and p38 pathways both
partially abrogated FGF-2 ⁄ heparin- and ... (1 : 200, in saponin–BSA) for 1 h in the
dark at 25 °C, rinsed in NaCl ⁄ P
i
(3 · 5 min) and nuclei
stained with DAPI (0.3 nm in NaCl ⁄ P
i
, 10 min in...
... understanding of system capa-
bilities. Of the remaining 66% of inputs (2166)
which were within the functionality of the system,
68% were in grammar. On the within functionality
portion of the ... and pen input, includ-
ing both pointing and handwriting (Figure 1). Our
application task also differs, focusing on search
and browsing of a large database of mov...
... apoptosis [73]. The authors of this study
ascribe the regulation of outgrowth of limb buds and
patterning of the digits to the chicken AP-2.
The role of AP-2a was further studied in zebrafish.
It ... role of AP-2a and AP-2e
in chondrogenesis. Overview of the differen-
tiation stages during chondrogenesis and
the involvement of transcription factors
(he...
... per
monomer of poly(dT), showing that the changes were
mainly due to the binding of the first DNA, while the
binding of the second DNA had less in uence
(Fig. 5A). To ensure that the estimation of the ... located, and are not found at the ATP-binding site
or the subunit–subunit interface of the Rad51 filament.
Therefore, the Rad51 L1 and L2 loops may also be...
... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in
hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 ... neurogenesis
and neuronal migration in different parts of the mouse
brain. HSF1 and HSF2 might interact in the develop-
ing mouse brain in a stage- and tis...
... role in maintaining
SNase tertiary structure.
Our CD and DSC data show that the W140 in
SNase is the amino acid responsible for the stability of
the whole protein. However, in comparison with the
wild-type ... located in the C-terminal loop of SNase plays
an important role in protein stability and conforma-
tional integrity. During protein unfolding ⁄ refolding,...
... raised against the hemocyanin fraction show
staining of the two 75 kDa bands in Western blot, but do
not recognize any other proteins of the hemolymph.
Although we expected that each of these bands ... observed in SDS/PAGE and in 2D PAGE (Figs 1 and
2; Table 1).
The N-terminal amino acid sequences (see above) allow
the assignment of the HcA clone to the major s...
... headword of the node.
In the following, the units of PIQ are bits.
Conclusion
Among the feature types in the same structural
position of the parsing tree, the predictive
information quantity of lexical ... sequence
containing the leaf nodes of the partial parsing
tree rooted by the current node, representing the
final objectives to be derived from the c...
... arginines called the arginine
fingers. The roles of arginine fingers have been
explored in several AAA+ proteins [3–8]. The arginine
finger is typically located in the subunit interface, and
interacts ... conserved
WalkerA and WalkerB motifs, and two arginines (AAA-1) or one arginine
(AAA-2). Here, we investigated the roles of these arginines (Arg322,
Arg323, and Ar...