Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf

... bold.bThe type of mutation: natural polymorphism (P), mutation appearing only in drug resistance (R, seeFig. 1). If two mutations occurred and one of them was occurring only in drug resistance, ... Stock solutions and dilutions weremade in distilled water and the peptide concentrations weredetermined by amino-acid analysis.Construction and puriﬁcation of HIV-1 PR mutants HIV-1 PR (HIVHXB2CG) ... Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites Anita Fehe´r1, Irene T. Weber2,Pe´ter Bagossi1,Pe´ter...

Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

... absence of ligand, the WPD loop of PTP1B and RPTPa adoptsan open (inactive) conformation, and upon ligand bind-ing, it adopts a closed (active) conformation (Fig. 3A).In oxidized PTP1B [12,13] and ... of InsP6to PhyAsr (Table 1). Given the absence of structural changes as a function of ionic strength and ligand binding, the effect of ionic strength on catalyticactivity is probably not of ... 136.4) and the wtorsion angle of Gly255 (18.9 to )157.9) upon oxida-tion. This large rotation of the peptide bond betweenAla254 and Gly255 results in a 4.12 A˚movement of Gly255 Ca and a...

Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efﬁcacy pdf

... impact of silencingTRBP and Dicer on the function of the fully paired and mismatched sequences, we wished to examineFig. 1. Effect of guide strand 5¢ end mismatch on silencing efﬁcacy of siRNAs. ... the Dicer and TRBPcomplexes are assumed to contain only one moleculeeach of protein and siRNA. As further conﬁrmation of the identities of the complexes, we showed that forma-tion of both the ... characterization of Dicer and TRBP complexes.Fig. S5. Effect of a terminal mismatch at the guidestrand 5¢ end on siRNA–TRBP complex formation (sequence 306).Fig. S6. Effect of a terminal mismatch...

Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx

... Ig-blocus.Acetylation of H3 and H4 histones in cells deletedin region IIAcetylation of H3 and H4 histones is enhanced in and around potentially active and transcribed genesABCFig. 2. Construction of DT40 ... role of this region in the transcription of theIg-b gene. Deletion of region III decreased the expres-sion of Ig-b mRNA to 40% of the expression in prede-letion cells (Fig. 4A). Region III ... kb deletion (16 kb Del) in one allele of the Ig-b locus (Fig. 1). Introduction of the 16 kb Delconstruct into DT40 ⁄ Cre cells resulted in two deletionclones. In one of these two clones, the...

Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx

... several cytoplasmic ligands. It is activa-ted by millimolar concentrations of ATP and micromo-lar Ca2+, and inhibited by higher concentrations(> 100 lm)ofCa2+ and by millimolar Mg2+. ... pore [10]. Results about the effect of theluminal (trans) calcium on the activity of the RyR1 arecontroversial depending on experimental conditions.Inhibition of the channel was described ... al. and Herrmann-Franket al. have found activation of the channel at100–250 lm and inactivation at higher luminal calciumconcentrations [15,16]. As the effect of the luminal cal-cium concentration...

Tài liệu Báo cáo khoa học: "Effect of Cross-Language IR in Bilingual Lexicon Acquisition from Comparable Corpora" pot

... termcorrespondences are estimated, in terms of both computational complexity and the performance of precise estimation of bilingual term correspondences.1 IntroductionTranslation knowledge acquisition ... situ-ation. One limitation of the corpus-based trans-lation knowledge acquisition approach is that thetechniques of translation knowledge acquisitionheavily rely on availability of parallel/comparativecorpora. ... expressions, and collocational expressionsfrom the collection of bilingual news articles on WWW news sites (Utsuro and others, 2002).Figure 1 illustrates the overview of our frame-work of translation...

Tài liệu Báo cáo khoa học: Role of hydroxyl group and R/S conﬁguration of isostere in binding properties of HIV-1 protease inhibitors docx

... the formation of hydrogen bondnetwork increase the number of possible configurations and conformation states of the complex. Calculation of energydifferences between the states containing different ... different conformations of the isostere of inhibitor fi tting well the electron d ensity weremodeled (Fig. 7). In the first conformation, the NH group of Phe i n position P1¢ makes only one hydr ... using c utoffs of 3.6 A˚ and 4.1 A˚[19]. Allhydrophobic c ontacts and h ydrogen bonds that are involvedin the inhibitor OE binding ar e summarized in Table 3.Conformation of isostere. Two different...

Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

... action of EPA and DHA (Eur. J. Biochem. 271) 4465Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAsInduction of cyclin D1 is one of the e arliest effects of mitogenic ... binding elements may contribute to the modu-lation of egr-1 gene expression (Fig. 4B).Effects of n-3 and n-6 PUFAs on the synthesis of caveolin-1 and caveolin-3 and on the location of p42/44 MAPK ... the d iffering effects of n-6 and n-3 PUFAs on Egr-1 mRNA accumulation are consistent with their a ctionupon the activation of cyclin D1 transcription.Inﬂuence of n-3 PUFAs on egr-1 promoter...

Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

... Abstract We demonstrate applications of psycholin-guistic and sublexical information for learn-ing Chinese characters. The knowledge about the grapheme-phoneme conversion (GPC) rules of languages ... exploration of using the combination of audio and visual stimuli. In addition to pictograms, more than 80% of Chinese characters are phono-semantic characters (PSCs, henceforth) (Ho and Bryant, ... similar pronunciation when it serves as a PC in the hosting character, e.g., “賣” and “讀” are pronounced as /mai4/ and /du2/, respectively. In contrast, the pro-nunciations of “匋”, “淘”, “陶”, and...

Tài liệu Báo cáo khoa học: Consequences of COP9 signalosome and 26S proteasome interaction doc

... lid, which has consequences for 26S proteasomepeptidase activity. In addition, we demonstrate theessential role of the PCI domain of CSN2 for complexformation and consequences of permanently ... Theconsequence of permanent Flag-CSN2 overexpression was de-novo assem-bly of the CSN complex connected with an accelerated degradation of p53 and stabilization of c-Jun in B8 cells. The possible role of ... ﬁltration size-fractionation of material from cauliﬂower in the presence of ATP and phosphatase inhibitors indicated that the CSN1 and CSN6 subunits coelute in the same fractions as subunits of the...

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