Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... the production of
methionine and S-AdoMet [6,7]. Furthermore, MetS is
the only human enzyme that metabolizes methyltetra-
hydrofolate to tetrahydrofolate, thereby facilitating the
recycling of ... a cofactor [1]. MetS catalyses the transfer
of the methyl group from 5-methyltetrahydrofolate to
homocysteine via the CH
3
-Cbl cofactor, with cycling
of cobalamin between the...
... in the separ-
ation of the daughter cells at the end of cell division
and in cellular autolysis [9], where it mediates the
release of toxins that damage the host tissues and
allows the entry of ... the structures of both
the ligated and unligated forms of C-LytA, due to the
insolubility of the protein at the required concentra-
tions. The recently...
... [51,52].
The O of Ser90 and the S of Cys266 of pea FNR are close
to N5 and O4 of the isoalloxazine, which are involved in
hydride transfer. The hydroxy group of Ser90 could accept a
hydrogen bond and ... presence of the inhibitor, and disrupting the electron
transfer between the flavin and the second substrate mainly
causes enzyme inhibition by Zn-ferr...
... of CYPD
or its inhibition by cyclosporin A significantly
enhanced the rate of F
0
F
1
-ATP synthase-mediated
regeneration of ATP consumed by arsenolysis in the
matrix and decreased the extent of ... ablation of the ppif gene or inhibi-
tion of CYPD binding on F
0
F
1
-ATP synthase by
cyclosporin A led to a disinhibition of the ATPase,
resulting in accelerate...
... DFQPP-YFPPPY QPLPYHQSQDP YSHVN-DPYS LNPLHQ-PQ Q
Gamma GVA EYQPPPYFPPPY QQLAYSQSADP YSHLG-EAYAAAINPLHQPAPTGSQ
Epsilon PAATAAAEFQPP-YFPPPYPQPPLPYGQAPDAAAAFPHLAGDPYGG-LAPLAQPQPP
Delta TTG TEFASP-YFSTNHQYTPL-HHQSFHYEFQHSHPAVTPDAYSLNSLHHSQQYYQQ ... of the AP-2 structure.
Expression patterns of AP-2 molecules
and functional implications
The expression and function of AP-2 isofo...
... THP-1 cells, and the subsequent
expressions of SR-BI were analysed by real-time PCR and western blot.
The binding and transcriptional activities of KLF4 to the SR-BI promoter
were detected by electrophoretic ... to
synthesize the complimentary cDNA using the First Strand
Synthesis Kit (Invitrogen). The cDNA from this synthesis
was then used in quantitative real-time...
... methylglyoxal and 3-deoxygluco-
sone in the glycation of proteins by glucose. Biochem J
344, 109–116.
23 Atkins TW & Thornalley PJ (1989) Erythrocyte gly-
oxalase activity in genetically obese ... Group, The Heart Research Institute, Camperdown, Sydney, NSW, Australia
2 Department of Health Sciences, University of Technology Sydney, NSW, Australia
3 Faculty of Medicine, Un...
... ADP-ribosylation of Ras
requires the Leu-428 residue
Ras is modified by the ADP-ribosylating activity of
ExoS expressed and delivered into the eukaryotic cells
by genetically modified Y. pseudotuberculosis ... fact that before the
ADP-ribosylation activity of translocated ExoS causes
cell death, the infected cells undergo a morphology
change whereby they round up due to...
... from the 350 nm band formed by
Co- and Ni-AGAO, the LCAO band was not affected by
the admission of oxygen in solution. Thus, the inactivated
protein was unable to hydrolyze the aldehyde and to ... inactivated,
slowly formed a band at 420 nm, typical of the 2-hydraz-
inopyridine adduct of TPQ. The final band intensity
matched the residual activity of the soluti...
... essentially unaffected. Although neither of the lig-
ands tested is a physiological partner of cytochrome c
3
, the small changes
observed for the thermodynamic properties of cytochrome c
3
bound to
these ... essentially
undisturbed by the replacement of Fe by Zn in the
rubredoxin given the identical structures of the two
protein forms [38,39]. Therefore, at the...