... of the hairpin loop in mussel defensin activity (Eur. J. Biochem. 270) 2811
From our observations, it is not possible to infer whether
the key role of the b-hairpin loop of MGD1 (loop 3) in
antimicrobial ... Ôresidues in the protruding domain consisting
of the type VI b-turn and the first part of b-strand 3Õ (i.e. the
b-hairpin loop and part of...
... obtained indicate that the KIND2 domain
is necessary and sufficient for the targeting of v-KIND
to dendrites of neurons.
To investigate the MAP2-binding characteristics of
the KIND domain protein ... in the central domain of MAP2
contain the v-KIND binding core module
MAP2 consists of three main structural domains: the
cAMP-dependent protein kinase regulatory subunit...
... obese mice
In order to gain insights into the potential biologically
relevant role of miR-27 in the regulation of adipose tis-
sue functions in vivo, we examined the expression of
miR-27 in the genetically ... together, these results illustrate
a critical and specific role of miR-27 in the regulation
of adipogenic differentiation.
miR-27 prevents the inducti...
... and the intersubunit disulfides that
link the two subunits of BS-RNase. Monomeric derivatives
of the protein are inactive as cytotoxic agents when they are
prepared by reductive cleavage of the intersubunit ... for its display of cytotoxic activity
[3]. This conclusion was based on the lack of cytotoxic
activity in a monomeric derivative of the protein obtaine...
... that the Trp169–
His210 pair functions in the high catalytic activity of this
protease at pH9 [10]. Further interest in the aromatic
stacking is in the role of the electrostatic properties in
enzymatic ... solvent. The aromatic stacking regulates the
low activity at neutral pH and the high activity at alkaline
pH due to the interference of the hydroge...
...
disambiguated word meaning.
It is the in interaction of the results of
these asynchronous processes that the process of
comprehension is defined.
The processes are independent of the know-
ledge ... affected.
The study includes off-line picture naming
which forces use of articles in all of the above
contexts, as well as on-line production of these
morph...
... near
the N- and C-termini of the linkers: this suggests that
a mobile connection with both the catalytic domain
and the binding module is required for the function of
the nanomachine. Furthermore, ... C-terminal domain. URLs of the relevant
genome databases are given in Table S1. The linker
between the core enzyme and its C-terminal domain was
defined as the regio...
... Yer-
sinia, the increased synthesis of LcrV triggered by the
activation of the system leads to the titration of LcrG,
which binds LcrV in a 1 : 1 complex. In turn, this
results in a release of the ... by the sug-
gestion that pH sensing by Salmonella involves modi-
fications in the assembly of the translocon, which
affect the pH gradient within the needle,...
... resulting in the induction of Hsp70 expression.
STAT3 is required for the induction of hsp70
promoter activity by Hsp105b
To further demonstrate that STAT3 plays essential
roles in the activation of ... HSF1, binds to the region
between )206 and )187 bp of the hsp70
promoter
Next, we investigated protein binding to the region
between )206 and )187 bp of the hsp70...
... WhiB proteins except WhiB2, the amino acid imme-
diately after the C-terminal cysteine of the CXXC
motif is proline (Fig. S6). In WhiB2 the absence of
proline and therefore of the kink might ... out. Interestingly, in WhiB5 despite the insertion
of an extra amino acid between the two cysteines of
the CXXC motif, the protein retained disulfide reduc-
tase acti...